Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3159797..3161344 Replicon chromosome
Accession NZ_CP024923
Organism Sphingomonas sp. Cra20

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CVN68_RS14195 Protein ID WP_100282774.1
Coordinates 3159797..3161098 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CVN68_RS14200 Protein ID WP_100282775.1
Coordinates 3161099..3161344 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVN68_RS14160 3155085..3155423 + 339 WP_100282768.1 hypothetical protein -
CVN68_RS14165 3155420..3157012 + 1593 WP_100282769.1 PepSY domain-containing protein -
CVN68_RS14170 3157009..3157287 + 279 WP_100282770.1 hypothetical protein -
CVN68_RS14175 3157303..3157905 - 603 WP_100282771.1 hypothetical protein -
CVN68_RS14180 3158219..3158419 - 201 WP_100282772.1 sigma-70 family RNA polymerase sigma factor -
CVN68_RS14185 3158416..3158757 - 342 Protein_2823 antirestriction protein ArdC -
CVN68_RS14190 3159575..3159781 + 207 WP_100282773.1 AlpA family phage regulatory protein -
CVN68_RS14195 3159797..3161098 - 1302 WP_100282774.1 type II toxin-antitoxin system HipA family toxin Toxin
CVN68_RS14200 3161099..3161344 - 246 WP_100282775.1 helix-turn-helix domain-containing protein Antitoxin
CVN68_RS23270 3162312..3162989 + 678 WP_158298900.1 hypothetical protein -
CVN68_RS23275 3163689..3164339 + 651 Protein_2828 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(152-395)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-65)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 47786.32 Da        Isoelectric Point: 5.5250

>T89284 WP_100282774.1 NZ_CP024923:c3161098-3159797 [Sphingomonas sp. Cra20]
MARRSSTLRVLLNGRQVGWLSRAANGAIDFRYAQEWLDWEYVSPVSLSLPLDTRRYTGGAVTAVFDNLLPDNDDIRRRVA
GRVGAEGADVYSLLAAVGRDCVGALQFLPEDEEASPAGTVEAEPLEDDDVAAMLRNLGRAPLGLERDDAFRISIAGAQEK
TALLWWEDRWNKPHGTTATTHIFKPQIGELPNGIDLSNSVENEHLCLTFLGALGMDVAQTRVATFGERPVLIVERFDRLW
ARDGRLLRRPQEDLCQALSVPPTRKYEDHGGPGVAEIMKVLAASDRPDIDRRALMKTLIAFWLLGATDGHAKNFSIFLSP
GGRFAATPIYDVLSAEPSLAAHQVNRRQMRLAMAIGDRRRYRLDEIAPRHFLQTAVRAGYDEESTREILHELRVTAEPAF
EAAVAAMPTGAPAALVEPIGVAIRQRVGQIDLL

Download         Length: 1302 bp

>T89284 NZ_CP024923:c3161098-3159797 [Sphingomonas sp. Cra20]
ATGGCGCGCCGGTCCTCGACCCTTCGGGTGCTTCTGAACGGCAGACAGGTCGGATGGCTATCCCGTGCGGCCAACGGCGC
CATCGACTTCCGCTACGCGCAGGAATGGCTCGACTGGGAATATGTGTCGCCGGTCTCGCTTTCGCTGCCGCTCGATACGC
GCCGCTATACCGGCGGTGCGGTCACGGCAGTGTTCGACAACCTTCTCCCGGACAATGACGACATCCGTCGCCGTGTCGCC
GGCCGGGTCGGCGCCGAAGGTGCCGATGTCTATAGTTTGCTGGCGGCTGTCGGGAGGGATTGCGTTGGCGCACTTCAGTT
CCTGCCCGAAGACGAAGAGGCCTCGCCTGCCGGCACTGTCGAAGCCGAACCCCTCGAAGACGACGACGTCGCTGCGATGC
TGCGCAACCTCGGCAGGGCGCCGCTGGGTCTGGAGCGCGACGATGCGTTTCGTATCTCGATTGCCGGCGCCCAGGAGAAG
ACCGCGTTGCTCTGGTGGGAAGACCGCTGGAACAAGCCACACGGCACGACAGCCACAACGCACATCTTCAAGCCGCAGAT
CGGCGAGCTTCCCAACGGGATCGATCTCTCGAACAGCGTCGAGAACGAGCATCTCTGCCTGACCTTCCTTGGCGCCCTCG
GCATGGACGTCGCTCAAACCCGCGTGGCGACTTTTGGAGAGCGGCCGGTGTTGATCGTCGAGCGGTTTGACCGGCTGTGG
GCGCGTGACGGGCGCCTGCTTCGACGTCCGCAGGAGGATTTGTGCCAGGCGCTGTCCGTGCCGCCGACGCGCAAGTACGA
GGATCATGGCGGACCGGGCGTCGCCGAGATCATGAAGGTGCTGGCCGCCAGTGACCGGCCGGATATCGACCGCCGCGCGC
TGATGAAGACGCTCATCGCCTTCTGGCTGCTCGGCGCCACCGACGGGCATGCGAAGAATTTCAGCATCTTCCTGTCGCCC
GGCGGGCGTTTCGCGGCGACCCCCATCTACGATGTGCTGTCAGCGGAGCCGAGCCTTGCCGCGCATCAGGTGAACCGTCG
GCAGATGCGTCTTGCGATGGCGATCGGCGACCGGCGCCGATATCGGCTCGATGAGATTGCGCCGCGTCACTTCCTGCAGA
CCGCGGTCCGCGCGGGCTATGACGAGGAATCCACGCGCGAGATTTTGCACGAGCTGCGCGTGACCGCAGAGCCGGCGTTC
GAGGCTGCGGTCGCTGCTATGCCGACGGGTGCGCCGGCGGCGCTGGTAGAGCCGATCGGTGTCGCGATCCGGCAGCGCGT
CGGGCAGATCGATCTGCTGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8821.11 Da        Isoelectric Point: 10.7950

>AT89284 WP_100282775.1 NZ_CP024923:c3161344-3161099 [Sphingomonas sp. Cra20]
MVSIIRSSQSLGAALRSARRAAGLTQKELGARTNLRQATISSLENGEAGTLETLFTILTYLKLELRLSERSRSAPALDEI
F

Download         Length: 246 bp

>AT89284 NZ_CP024923:c3161344-3161099 [Sphingomonas sp. Cra20]
ATGGTTTCCATCATCAGATCCTCTCAAAGCCTCGGTGCCGCATTGCGAAGCGCTCGACGCGCGGCGGGACTTACCCAAAA
GGAGCTTGGGGCACGAACGAACCTGCGTCAGGCGACGATCTCGAGCCTGGAGAACGGCGAGGCAGGTACTCTCGAAACTC
TGTTCACGATACTGACCTATCTGAAGCTGGAACTGCGGCTGTCGGAGCGCAGCCGGTCAGCGCCCGCGCTTGACGAGATC
TTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References