Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 529422..529938 Replicon chromosome
Accession NZ_CP024916
Organism Klebsiella pneumoniae strain NH54

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag CU643_RS02655 Protein ID WP_009486548.1
Coordinates 529654..529938 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CU643_RS02650 Protein ID WP_002886901.1
Coordinates 529422..529664 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU643_RS02635 525450..526190 + 741 WP_009486551.1 KDGP aldolase family protein -
CU643_RS02640 526257..527411 + 1155 WP_002886900.1 lactonase family protein -
CU643_RS02645 527434..529344 + 1911 WP_009486549.1 BglG family transcription antiterminator -
CU643_RS02650 529422..529664 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CU643_RS02655 529654..529938 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CU643_RS02660 529942..530406 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CU643_RS02665 530714..532852 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CU643_RS02670 533209..533952 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CU643_RS28970 533955..534128 - 174 WP_032433782.1 hypothetical protein -
CU643_RS02675 534213..534521 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T89259 WP_009486548.1 NZ_CP024916:529654-529938 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T89259 NZ_CP024916:529654-529938 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT89259 WP_002886901.1 NZ_CP024916:529422-529664 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT89259 NZ_CP024916:529422-529664 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References