Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4079292..4079971 Replicon chromosome
Accession NZ_CP024908
Organism Enterobacter hormaechei subsp. xiangfangensis strain OSUKPC4_L

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CUN65_RS20320 Protein ID WP_032608412.1
Coordinates 4079292..4079633 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CUN65_RS20325 Protein ID WP_020456353.1
Coordinates 4079654..4079971 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUN65_RS20285 4074785..4075036 + 252 WP_032608418.1 hypothetical protein -
CUN65_RS20290 4075109..4075333 + 225 WP_032608417.1 hypothetical protein -
CUN65_RS20295 4075392..4075640 + 249 WP_032608415.1 bacteriocin immunity protein -
CUN65_RS20300 4075755..4076126 + 372 WP_032608414.1 hypothetical protein -
CUN65_RS20305 4076206..4076679 - 474 WP_072163380.1 SymE family type I addiction module toxin -
CUN65_RS20310 4076980..4077849 + 870 WP_032608413.1 HNH endonuclease -
CUN65_RS20315 4078030..4079037 - 1008 WP_020456355.1 restriction endonuclease -
CUN65_RS20320 4079292..4079633 - 342 WP_032608412.1 TA system toxin CbtA family protein Toxin
CUN65_RS20325 4079654..4079971 - 318 WP_020456353.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CUN65_RS20330 4079989..4080210 - 222 WP_032608411.1 DUF987 domain-containing protein -
CUN65_RS20335 4080219..4080698 - 480 WP_020456351.1 DNA repair protein RadC -
CUN65_RS20340 4080741..4080959 - 219 WP_020456350.1 hypothetical protein -
CUN65_RS20345 4080969..4081427 - 459 WP_032608410.1 antirestriction protein -
CUN65_RS20350 4081533..4081733 - 201 WP_050596949.1 DUF905 family protein -
CUN65_RS20355 4081861..4082727 - 867 WP_032608409.1 hypothetical protein -
CUN65_RS20360 4082966..4083649 - 684 WP_020456346.1 DeoR family transcriptional regulator -
CUN65_RS20365 4083858..4084682 - 825 Protein_3907 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 4069887..4111966 42079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12747.73 Da        Isoelectric Point: 9.0060

>T89252 WP_032608412.1 NZ_CP024908:c4079633-4079292 [Enterobacter hormaechei subsp. xiangfangensis]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T89252 NZ_CP024908:c4079633-4079292 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11846.39 Da        Isoelectric Point: 5.5403

>AT89252 WP_020456353.1 NZ_CP024908:c4079971-4079654 [Enterobacter hormaechei subsp. xiangfangensis]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 318 bp

>AT89252 NZ_CP024908:c4079971-4079654 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References