Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2309433..2310172 Replicon chromosome
Accession NZ_CP024908
Organism Enterobacter hormaechei subsp. xiangfangensis strain OSUKPC4_L

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag CUN65_RS11530 Protein ID WP_032609220.1
Coordinates 2309687..2310172 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag CUN65_RS11525 Protein ID WP_003857131.1
Coordinates 2309433..2309699 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUN65_RS11505 2304909..2305895 + 987 WP_003857123.1 DUF979 domain-containing protein -
CUN65_RS11510 2305905..2306900 + 996 WP_032666403.1 DUF2891 domain-containing protein -
CUN65_RS11515 2306922..2308310 - 1389 WP_032609222.1 MFS transporter -
CUN65_RS11520 2308440..2309369 + 930 WP_032609221.1 LysR family transcriptional regulator -
CUN65_RS11525 2309433..2309699 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
CUN65_RS11530 2309687..2310172 + 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
CUN65_RS11535 2310350..2311642 - 1293 WP_032609218.1 glycoside hydrolase -
CUN65_RS11540 2311747..2312505 - 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
CUN65_RS11545 2312592..2313176 + 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
CUN65_RS11550 2313261..2314019 + 759 WP_023314159.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T89250 WP_032609220.1 NZ_CP024908:2309687-2310172 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T89250 NZ_CP024908:2309687-2310172 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGGACGTGTAACAGCGCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCATTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCACTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCCTCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT89250 WP_003857131.1 NZ_CP024908:2309433-2309699 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT89250 NZ_CP024908:2309433-2309699 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References