Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2395509..2397284 Replicon chromosome
Accession NZ_CP024906
Organism Paraburkholderia caledonica strain PHRS4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CUJ87_RS28215 Protein ID WP_114199819.1
Coordinates 2395509..2396399 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CUJ87_RS28220 Protein ID WP_114199821.1
Coordinates 2396400..2397284 (+) Length 295 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ87_RS28185 2390869..2391942 - 1074 WP_114199811.1 porin -
CUJ87_RS28190 2392382..2392696 + 315 WP_020068683.1 non-heme iron oxygenase ferredoxin subunit -
CUJ87_RS28195 2392698..2393009 + 312 WP_020068684.1 hypothetical protein -
CUJ87_RS28200 2393059..2394162 + 1104 WP_114199813.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CUJ87_RS28205 2394155..2394922 + 768 WP_114199815.1 SDR family oxidoreductase -
CUJ87_RS28210 2394949..2395476 + 528 WP_114199817.1 cupin domain-containing protein -
CUJ87_RS28215 2395509..2396399 + 891 WP_114199819.1 alpha/beta fold hydrolase Toxin
CUJ87_RS28220 2396400..2397284 + 885 WP_114199821.1 IclR family transcriptional regulator Antitoxin
CUJ87_RS28225 2397281..2398093 + 813 WP_114199823.1 SDR family oxidoreductase -
CUJ87_RS28230 2398086..2399744 + 1659 WP_027778993.1 thiamine pyrophosphate-binding protein -
CUJ87_RS28235 2399737..2400567 + 831 WP_027778992.1 aspartate dehydrogenase -
CUJ87_RS28240 2400617..2402107 + 1491 WP_110404653.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-277)

Antitoxin

Transcription regulator IclR, N-terminal

(29-77)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 31115.41 Da        Isoelectric Point: 6.9019

>T89240 WP_114199819.1 NZ_CP024906:2395509-2396399 [Paraburkholderia caledonica]
MSAVPSAAVDANATLEARLARFPARQIELANQRVLSYLEADGAANDALPLVLLHGIGSGAASWVQQLEALGANRRVLAWD
APGYGMSTPVAPESPVASDYASVLTEWLDALHIERCVLVGHSLGAIIAGAFAAIHPQRVSGLLLLSPAGGYGAACADVRE
TKRDQRLAMLNELGPHGLADKRSANMLSPHASDEARAWVRWNMSRVIVRGYAQATHLLANADLAADLVRFKGRINVAVGA
DDTITTPAACERLALVAGTQLQVVPRAGHAGYIEASAAYTAIIDTFCRASAGQRSQ

Download         Length: 891 bp

>T89240 NZ_CP024906:2395509-2396399 [Paraburkholderia caledonica]
ATGTCCGCAGTCCCGTCCGCCGCCGTCGATGCAAACGCCACGCTCGAAGCGCGCCTTGCGCGCTTTCCGGCGCGGCAGAT
CGAACTGGCGAATCAACGTGTGCTGAGCTATCTCGAAGCGGACGGTGCCGCGAACGACGCGTTGCCGCTCGTCTTGCTGC
ACGGCATCGGTTCGGGCGCGGCTTCGTGGGTGCAGCAACTCGAAGCACTGGGCGCAAACCGCCGCGTGCTTGCATGGGAC
GCGCCTGGTTACGGGATGTCCACGCCGGTAGCACCGGAGTCGCCTGTCGCCAGCGACTACGCAAGCGTGCTGACGGAATG
GCTCGACGCACTTCACATTGAACGTTGCGTGCTGGTCGGCCATTCGCTTGGCGCGATCATCGCCGGTGCGTTTGCTGCGA
TCCATCCGCAGCGCGTGTCCGGCCTCTTGCTGTTATCGCCGGCAGGCGGTTACGGCGCGGCCTGCGCAGACGTCCGCGAG
ACGAAGCGCGATCAGCGCCTCGCCATGTTGAACGAACTCGGCCCGCACGGCCTCGCCGACAAGCGCAGCGCCAACATGTT
GTCCCCGCACGCAAGCGACGAAGCCCGCGCATGGGTGCGCTGGAACATGTCGCGCGTGATTGTTCGCGGGTACGCGCAGG
CTACGCATCTGCTTGCCAACGCCGACCTCGCCGCCGACCTCGTGCGCTTCAAAGGCCGCATCAATGTCGCGGTCGGTGCC
GACGACACCATTACGACTCCCGCAGCCTGCGAGCGGCTCGCGCTCGTCGCGGGGACCCAATTGCAAGTCGTGCCACGCGC
GGGGCACGCCGGCTATATCGAAGCATCTGCCGCGTACACCGCGATCATCGACACGTTCTGCCGCGCAAGCGCCGGACAAC
GGAGCCAATGA

Antitoxin


Download         Length: 295 a.a.        Molecular weight: 32787.17 Da        Isoelectric Point: 5.8793

>AT89240 WP_114199821.1 NZ_CP024906:2396400-2397284 [Paraburkholderia caledonica]
MTPDTINERDAEDDRNDSSDDTGYRVPGLERGLKILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQTLESLGFLERADK
DRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRDETGLTTHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAYA
TTHGQVLMGDMTLDELKKLYPEPELERFTRQTPATVEDLYERVRDDARRGFAISESSFERGISVVSAPVRNDTGRIVAVI
TTTIPRQEIDASLLDSGLVDKVRRAADELSQRLNYRPGNASNAGSKYMKALGLK

Download         Length: 885 bp

>AT89240 NZ_CP024906:2396400-2397284 [Paraburkholderia caledonica]
ATGACGCCCGACACTATCAACGAGCGTGACGCTGAAGACGACCGCAACGACAGCAGCGACGACACGGGCTACCGGGTGCC
GGGTCTGGAGCGCGGCCTGAAGATCCTCACGGAGTTCTCGCCTCGCGAGCCGGTGCTCGGCGCTCCGGAATTGTCGCGCC
GCTTGAAGATTCCGCGCACGACGGTCTTCCGTCTGCTGCAAACGCTCGAATCGCTTGGCTTTCTCGAACGCGCCGACAAG
GACCGCAACTACCGACTCGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACTTGAGCTCGCTCGAATTGACTGACCTCGG
CTTGCCGATCATCGAAGCGTTGCGCGACGAAACGGGCCTCACGACGCACATTGTGATTCGCGACGGACGCGATGTCGTAT
TCGTCGCAAAGGCGCAAAGCCACGCGCCGATTTTCAGTTCCGTGAAAGTGAACGTCGGCACTCGCTTGCCCGCGTATGCA
ACGACGCACGGCCAGGTGTTGATGGGCGACATGACGCTCGACGAGTTGAAGAAGCTCTATCCCGAGCCGGAACTCGAACG
CTTCACGAGGCAGACGCCTGCGACCGTGGAGGACCTCTATGAACGGGTCCGCGACGACGCGCGGCGCGGTTTCGCAATCA
GCGAGTCGTCGTTCGAGCGCGGCATTTCGGTGGTCAGCGCGCCGGTGCGCAATGACACCGGGCGCATCGTCGCCGTGATC
ACGACGACGATTCCGCGCCAGGAGATAGACGCATCGCTGCTCGACAGCGGTCTCGTCGACAAGGTACGGCGCGCGGCCGA
CGAACTGTCGCAACGGCTCAACTACCGGCCGGGCAATGCATCGAACGCGGGCAGCAAATACATGAAGGCATTGGGGCTCA
AATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References