Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1008532..1010365 Replicon chromosome
Accession NZ_CP024903
Organism Burkholderia pyrrocinia strain mHSR5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CUJ89_RS21990 Protein ID WP_114179547.1
Coordinates 1008532..1009428 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CUJ89_RS21995 Protein ID WP_114179548.1
Coordinates 1009508..1010365 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ89_RS21960 1003910..1004989 - 1080 WP_114179542.1 porin -
CUJ89_RS21965 1005437..1005754 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
CUJ89_RS21970 1005756..1006067 + 312 WP_114179543.1 hypothetical protein -
CUJ89_RS21975 1006123..1007193 + 1071 WP_114179544.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CUJ89_RS21980 1007186..1007956 + 771 WP_114179545.1 SDR family oxidoreductase -
CUJ89_RS21985 1007986..1008513 + 528 WP_114179546.1 cupin domain-containing protein -
CUJ89_RS21990 1008532..1009428 + 897 WP_114179547.1 alpha/beta fold hydrolase Toxin
CUJ89_RS21995 1009508..1010365 + 858 WP_114179548.1 IclR family transcriptional regulator Antitoxin
CUJ89_RS22000 1010445..1011242 + 798 WP_114179549.1 SDR family oxidoreductase -
CUJ89_RS22005 1011235..1012902 + 1668 WP_114179550.1 thiamine pyrophosphate-binding protein -
CUJ89_RS22010 1012895..1013710 + 816 WP_114179551.1 aspartate dehydrogenase -
CUJ89_RS22015 1013783..1015273 + 1491 WP_114179552.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30711.06 Da        Isoelectric Point: 7.9882

>T89235 WP_114179547.1 NZ_CP024903:1008532-1009428 [Burkholderia pyrrocinia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGVSTPVHCASPASADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYTQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDMQRGLV

Download         Length: 897 bp

>T89235 NZ_CP024903:1008532-1009428 [Burkholderia pyrrocinia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCGGAGCAGCGTTG
CGCGGCCGGTGCGGCGGGCACGATCGGTTATCGCGAGGCCGGTGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGTTGC
TGCACGGGATCGGCTCGGGTGCCGCATCGTGGGTCCGCCAGCTCGACGCGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGCTATGGCGTGTCGACGCCCGTGCACTGTGCGTCGCCGGCCTCAGCCGATTACGCCGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATTGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTCTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACACGC
GAATCGCGCCGCGACGCGCGGCTCGCAATGCTCGCTGAACTCGGCCCGGCCGGTCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCGGGTTTCGCGAGCGAGGATGCCCGCGCCTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACACGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTGGCAAGCGATCTCGCGGGCTTTCGCGGTCGCACGGCCGTGGCGGTCGGT
GCGAACGACGCGATCACGCCGCCCGCTGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGTTGCAGGTGATTCCGCA
GGCCGGTCATGCCGGCTACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACGCGTTCTGTCGGCAATGCGACATGC
AGCGAGGACTGGTATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31256.77 Da        Isoelectric Point: 6.7654

>AT89235 WP_114179548.1 NZ_CP024903:1009508-1010365 [Burkholderia pyrrocinia]
MSEPLQQPESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPSTVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
KPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLK

Download         Length: 858 bp

>AT89235 NZ_CP024903:1009508-1010365 [Burkholderia pyrrocinia]
ATGAGCGAACCGCTGCAACAACCCGAATCCGAGAACGCGAAGGCCGAGGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAGTTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGTGCGGACAAGGATCGCAACTACAAG
CTCGGCATTGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAACTGACCGATCTCGGCTTGCCCGTGATCGA
GAGCTTGCGCGATGCAACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCACATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCACGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGTCGACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGACGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGTATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAGGATCGTTGCGTGCATCACGGTGACGGTGCCT
AAACCGGAGATCGACGCGGCGCTGATCGCGGACGGACTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTGAAGGCGTTAGGACTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References