Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 848561..849216 Replicon chromosome
Accession NZ_CP024903
Organism Burkholderia pyrrocinia strain mHSR5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CUJ89_RS21270 Protein ID WP_114179430.1
Coordinates 848797..849216 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CUJ89_RS21265 Protein ID WP_114181482.1
Coordinates 848561..848800 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ89_RS21240 843618..843857 - 240 WP_011659184.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CUJ89_RS21245 844055..844477 + 423 WP_114179426.1 amino acid-binding protein -
CUJ89_RS21250 844558..845241 - 684 WP_114179427.1 Fe2+-dependent dioxygenase -
CUJ89_RS21255 845238..845993 - 756 WP_114179428.1 sel1 repeat family protein -
CUJ89_RS21260 845997..848240 - 2244 WP_114179429.1 TonB-dependent siderophore receptor -
CUJ89_RS21265 848561..848800 + 240 WP_114181482.1 Arc family DNA-binding protein Antitoxin
CUJ89_RS21270 848797..849216 + 420 WP_114179430.1 type II toxin-antitoxin system VapC family toxin Toxin
CUJ89_RS21275 849309..850604 - 1296 WP_114179431.1 aspartate carbamoyltransferase -
CUJ89_RS21280 850839..850973 + 135 WP_027781077.1 entericidin A/B family lipoprotein -
CUJ89_RS21285 851069..851641 - 573 WP_114179432.1 permease -
CUJ89_RS21290 851854..852822 - 969 WP_114181483.1 DMT family transporter -
CUJ89_RS21295 852993..853787 - 795 WP_114179433.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15166.43 Da        Isoelectric Point: 5.7470

>T89234 WP_114179430.1 NZ_CP024903:848797-849216 [Burkholderia pyrrocinia]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVATLPEGRRRDWLHQSIEHRVMPVFRGRILPFDD
AASKAYASIRARARAAGNAIALSDGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAL

Download         Length: 420 bp

>T89234 NZ_CP024903:848797-849216 [Burkholderia pyrrocinia]
ATGATCCTTGTTGATACCAACGTCATTTCCGAGCCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGATGC
CCAGAACGTTGAAACACTGTTTCTGGCCGCGATCAGTCTCGCCGAAATGCGGTTCGGCGTCGCGACGTTGCCGGAAGGGC
GCAGGCGAGACTGGCTGCATCAAAGCATCGAGCATCGTGTCATGCCGGTGTTTCGCGGCCGGATTCTGCCGTTCGACGAT
GCGGCAAGCAAGGCGTACGCAAGCATTCGCGCGCGGGCACGCGCCGCGGGCAACGCGATTGCGCTCTCCGACGGCTACAT
CGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCACCGTTCGAAGCGGCGGGCCTCCGGGTGA
TCGATCCATGGGCGTTGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8714.00 Da        Isoelectric Point: 5.6864

>AT89234 WP_114181482.1 NZ_CP024903:848561-848800 [Burkholderia pyrrocinia]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVDLDVQRDKMPTDPMSFE

Download         Length: 240 bp

>AT89234 NZ_CP024903:848561-848800 [Burkholderia pyrrocinia]
ATGCCGGTAATCACCGTTCGAAATTTGCCCGACGAGGTCCATCGTGCCCTTCGGATCCGCGCAGCTCAGCACGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATCCTCGAGCAGGCCGTTTTACCGGGAGGGCGTCTCAAGTTGGGCACGCTGCTGGCGG
AAATCGGACGGGAGGCAGGCGGCGTCGATCTCGACGTTCAGCGCGACAAGATGCCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References