Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 768283..768806 Replicon chromosome
Accession NZ_CP024903
Organism Burkholderia pyrrocinia strain mHSR5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CUJ89_RS20920 Protein ID WP_114179380.1
Coordinates 768283..768549 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CUJ89_RS20925 Protein ID WP_114181472.1
Coordinates 768546..768806 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ89_RS20895 763619..764857 - 1239 WP_114179375.1 diaminopimelate decarboxylase -
CUJ89_RS20900 764967..765881 + 915 WP_114179376.1 LysR family transcriptional regulator -
CUJ89_RS20905 765937..766536 + 600 WP_114179377.1 GNAT family N-acetyltransferase -
CUJ89_RS20910 766658..767245 - 588 WP_114179378.1 DUF4142 domain-containing protein -
CUJ89_RS20915 767633..768256 - 624 WP_114179379.1 HAD hydrolase-like protein -
CUJ89_RS20920 768283..768549 - 267 WP_114179380.1 Txe/YoeB family addiction module toxin Toxin
CUJ89_RS20925 768546..768806 - 261 WP_114181472.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CUJ89_RS20930 769031..769474 + 444 WP_114179381.1 GNAT family N-acetyltransferase -
CUJ89_RS20935 769532..769750 + 219 WP_006480837.1 DUF1653 domain-containing protein -
CUJ89_RS20940 769825..771042 - 1218 WP_114181473.1 winged helix-turn-helix domain-containing protein -
CUJ89_RS20945 771417..772805 - 1389 WP_114179382.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10380.71 Da        Isoelectric Point: 9.4579

>T89233 WP_114179380.1 NZ_CP024903:c768549-768283 [Burkholderia pyrrocinia]
MSVRRALFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADAPQISI
VSCRYHYA

Download         Length: 267 bp

>T89233 NZ_CP024903:c768549-768283 [Burkholderia pyrrocinia]
ATGAGCGTACGCCGCGCGCTTTTTACTTCCGACGCGTGGGACGACTATGTCTATTGGCAGGGGCAAGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCCGAACCCTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGTCTGGTCTATGAGGCTGACGCCCCTCAGATCAGCATC
GTGTCCTGCCGCTACCACTACGCGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9771.04 Da        Isoelectric Point: 6.0717

>AT89233 WP_114181472.1 NZ_CP024903:c768806-768546 [Burkholderia pyrrocinia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LPEDDE

Download         Length: 261 bp

>AT89233 NZ_CP024903:c768806-768546 [Burkholderia pyrrocinia]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATCACACGTCGCGATGCGCCGAACGCCGTCATCATGTCGCAGGACTACTACGACAGCCTGATGGAGACGGTTCACT
TGCTGCGCTCGCCGGCCAACGTCGCCCATCTCGAACGCTCGATTGCGCAACTACGCAAGGGCAAGGCGAAAGAACACAAG
CTCCCCGAGGATGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References