Detailed information of TA system TA089232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 692068..693314
• Replicon: chromosome
• Accession: NZ_CP024903
• Organism: Burkholderia pyrrocinia strain mHSR5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CUJ89_RS20560
• Protein ID: WP_114179316.1
• Coordinates: 692068..692649 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CUJ89_RS20565
• Protein ID: WP_114179317.1
• Coordinates: 692757..693314 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUJ89_RS20545	687766..689796	-	2031	WP_114179313.1	MacB family efflux pump subunit	-
CUJ89_RS20550	689799..690992	-	1194	WP_114179314.1	efflux RND transporter periplasmic adaptor subunit	-
CUJ89_RS20555	691298..692026	-	729	WP_114179315.1	class I SAM-dependent methyltransferase	-
CUJ89_RS20560	692068..692649	-	582	WP_114179316.1	HD domain-containing protein	Toxin
CUJ89_RS20565	692757..693314	-	558	WP_114179317.1	helix-turn-helix domain-containing protein	Antitoxin
CUJ89_RS20570	693399..694037	-	639	WP_114179318.1	hypothetical protein	-
CUJ89_RS20575	694373..695776	+	1404	WP_114179319.1	DUF308 domain-containing protein	-
CUJ89_RS20580	695871..696449	+	579	WP_114179320.1	hypothetical protein	-
CUJ89_RS20585	696634..697365	+	732	WP_114179321.1	ribonuclease T2	-
CUJ89_RS20590	697502..698137	-	636	WP_114179322.1	cysteine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21328.93 Da
• Isoelectric Point: 5.1032

>T89232 WP_114179316.1 NZ_CP024903:c692649-692068 [Burkholderia pyrrocinia]
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTVSLDRALRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGHRA

Nucleotide

• Length: 582 bp

>T89232 NZ_CP024903:c692649-692068 [Burkholderia pyrrocinia]
ATGAACCCCGATACGATCCACGCACGACTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGTGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGTCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAAAGTGCGCACGAACGCGACGACCTGCTGACGCTGACGGTTTCGCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGCGTCGCCCGAAGCACGCGCGGCGAAGGCGC
TCGACAAGCTGGAGACGATCCTGCAACACAACCAGGGCAGCAATCCGCCTGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGACGCCGCGCCGCTGTTCAGCGCGATCCGCGACATCGTCGATGCGGACACGCAACGCAGGATCGA
CGCGGGCGGGCACCGCGCGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20212.23 Da
• Isoelectric Point: 10.7075

>AT89232 WP_114179317.1 NZ_CP024903:c693314-692757 [Burkholderia pyrrocinia]
MTASPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARVDSAGDRALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLPMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSMCRWTRMTLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT89232 NZ_CP024903:c693314-692757 [Burkholderia pyrrocinia]
ATGACCGCCTCACCGCTTCACACGCCACCGCTCGGCCCGCAACTGAAGCGCTGGCGCCTGCTGCACCGCGTGAAGCAGAG
CCACGCCGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAGGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCACGCGTCGATTCCGCGGGTGACCGCGCGCTCGCGCGGCTCATCGCTGGT
AGTGCTGGACGCATGCATCTCGTGTGCGATCTCACGCACCGCCTGCTCGCAAGCTCGCCGGCACGCGCGGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACGCCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACACGCTCGGCTGGCACGACCGCGCGGGGCCGCCCAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCATGTGCCGGTGGACGCGGATGACGCTGTCGGACGGCTCGGCCGCACGGCTCGTCGAAACGCTCTAG