Detailed information of TA system TA089231

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 15286..15805
• Replicon: chromosome
• Accession: NZ_CP024903
• Organism: Burkholderia pyrrocinia strain mHSR5

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: CUJ89_RS17650
• Protein ID: WP_114178681.1
• Coordinates: 15524..15805 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A807EGB1
• Locus tag: CUJ89_RS17645
• Protein ID: WP_034205945.1
• Coordinates: 15286..15534 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUJ89_RS17635	12783..13973	+	1191	WP_114178680.1	2-methylaconitate cis-trans isomerase PrpF	-
CUJ89_RS17640	14115..15167	+	1053	WP_114181422.1	CoA transferase	-
CUJ89_RS17645	15286..15534	+	249	WP_034205945.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CUJ89_RS17650	15524..15805	+	282	WP_114178681.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CUJ89_RS17655	15869..16312	-	444	WP_114178682.1	PaaI family thioesterase	-
CUJ89_RS17660	16617..18236	+	1620	WP_114178683.1	Tar ligand binding domain-containing protein	-
CUJ89_RS17665	18209..19318	-	1110	WP_114178684.1	AGE family epimerase/isomerase	-
CUJ89_RS17670	19430..20128	+	699	WP_114178685.1	MgtC/SapB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10869.79 Da
• Isoelectric Point: 10.3953

>T89231 WP_114178681.1 NZ_CP024903:15524-15805 [Burkholderia pyrrocinia]
MTFELAFLEPALKEWKKLDRIMRDQFKARLAERLENPRIPSAKLHGHPDRYKIKLSSVGYRLVYEVREAEVVVLVVAVGR
RERDAVYLAAMKS

Nucleotide

• Length: 282 bp

>T89231 NZ_CP024903:15524-15805 [Burkholderia pyrrocinia]
ATGACCTTTGAGCTTGCCTTTCTCGAACCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCATCATGCGCGATCAGTTCAA
GGCCAGACTCGCCGAACGGCTCGAGAACCCTCGCATTCCTTCGGCGAAGCTGCACGGTCATCCGGACCGCTACAAGATCA
AGCTGAGCAGTGTCGGCTATCGCCTCGTGTACGAAGTGCGCGAGGCGGAGGTCGTCGTACTGGTGGTCGCGGTGGGGCGT
CGCGAGCGCGATGCGGTCTATCTTGCAGCGATGAAAAGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8963.31 Da
• Isoelectric Point: 5.0636

>AT89231 WP_034205945.1 NZ_CP024903:15286-15534 [Burkholderia pyrrocinia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNVLADSRAKEKAVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT89231 NZ_CP024903:15286-15534 [Burkholderia pyrrocinia]
ATGCCCCACACCATCCTGGCTAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAACCCGATGGGAACCGTGGCGGCGGG
AGAGGGTTTCCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTATTGCATCCCGGCGAAGACATGGGAGGCGATGG
TCGAACGTCTCGAAGATATCGAAGACAACGTGCTGGCCGATTCGCGCGCCAAGGAGAAAGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A807EGB1