Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1908832..1909508 Replicon chromosome
Accession NZ_CP024902
Organism Burkholderia pyrrocinia strain mHSR5

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag CUJ89_RS09170 Protein ID WP_114177051.1
Coordinates 1909092..1909508 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag CUJ89_RS09165 Protein ID WP_114177050.1
Coordinates 1908832..1909095 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ89_RS09150 1904365..1906629 + 2265 WP_114177048.1 TonB-dependent siderophore receptor -
CUJ89_RS09155 1906716..1907555 + 840 WP_114177049.1 N(5)-hydroxyornithine transformylase PvdF -
CUJ89_RS09160 1907555..1908571 + 1017 WP_114178555.1 acetyltransferase -
CUJ89_RS09165 1908832..1909095 + 264 WP_114177050.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CUJ89_RS09170 1909092..1909508 + 417 WP_114177051.1 PIN domain-containing protein Toxin
CUJ89_RS09175 1909552..1910457 - 906 WP_114177052.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CUJ89_RS09180 1910426..1911499 - 1074 WP_114177053.1 hypothetical protein -
CUJ89_RS09185 1911843..1913006 + 1164 WP_114177054.1 amidohydrolase -
CUJ89_RS09190 1913123..1913368 + 246 WP_114178556.1 type II toxin-antitoxin system ParD family antitoxin -
CUJ89_RS09195 1913358..1913653 + 296 Protein_1723 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14508.64 Da        Isoelectric Point: 7.8887

>T89230 WP_114177051.1 NZ_CP024902:1909092-1909508 [Burkholderia pyrrocinia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGKKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T89230 NZ_CP024902:1909092-1909508 [Burkholderia pyrrocinia]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTGGTCCTGTCGCGGTT
GCAATCCTGCGTCAATGCGCAGCACCGGATCGTCGTATCGGCAATTACCTATGCCGAGATGCGGTTCGGTGCGGTCGGCA
AGAAGGCATCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTGGACGGCGTGCTGTCGTGGGATACGGCG
GCCGTGGACGCGACGGCCGCGATTCGCGCCGATCTCGCCGCGCGCGGCACGCCGATCGGCGCAAACGACGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGCGCGGTGCTCGTGACGAACAACGGTCGGGAATTCGGCCGTGTCGCGGGGCTGTCGCTCG
AGGACTGGGCGGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9706.89 Da        Isoelectric Point: 4.6310

>AT89230 WP_114177050.1 NZ_CP024902:1908832-1909095 [Burkholderia pyrrocinia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSFANEPLADADFLADRPAVVEAGRFDLSGSDG
TPTESGR

Download         Length: 264 bp

>AT89230 NZ_CP024902:1908832-1909095 [Burkholderia pyrrocinia]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCGATCCGCATCCCGAAGGACATGGAGTTCGAAGGAGTGAC
GGAGCTCGAGATCCGTCGCGAGGGCGATACGCTGCTGCTGCGCCCGGTGCGTCCCACGTGGACCTCGTTCGCGAACGAGC
CGCTGGCCGACGCCGATTTCCTCGCCGATCGCCCGGCCGTCGTCGAAGCCGGCCGCTTCGACCTGTCCGGCAGCGATGGC
ACACCGACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References