Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4188311..4188974 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name cptA Uniprot ID Q7N1C2
Locus tag PluTT01m_RS18295 Protein ID WP_011147734.1
Coordinates 4188311..4188727 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q7N1C1
Locus tag PluTT01m_RS18300 Protein ID WP_011147735.1
Coordinates 4188708..4188974 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS18275 4184288..4186021 - 1734 WP_011147730.1 single-stranded-DNA-specific exonuclease RecJ -
PluTT01m_RS18280 4186021..4186728 - 708 WP_011147731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PluTT01m_RS18285 4186752..4187663 - 912 WP_011147732.1 site-specific tyrosine recombinase XerD -
PluTT01m_RS18290 4187771..4188289 + 519 WP_041380273.1 flavodoxin FldB -
PluTT01m_RS18295 4188311..4188727 - 417 WP_011147734.1 protein YgfX Toxin
PluTT01m_RS18300 4188708..4188974 - 267 WP_011147735.1 FAD assembly factor SdhE Antitoxin
PluTT01m_RS18305 4189152..4190141 + 990 WP_011147736.1 tRNA-modifying protein YgfZ -
PluTT01m_RS18310 4190153..4190758 + 606 WP_011147737.1 HD domain-containing protein -
PluTT01m_RS18315 4191690..4192994 - 1305 WP_011147738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-135)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16363.34 Da        Isoelectric Point: 10.1464

>T89216 WP_011147734.1 NZ_CP024901:c4188727-4188311 [Photorhabdus laumondii subsp. laumondii]
VVLWKCDLRVSWHTQLISTCVHGAIALIVLFAPWPADDAIFWIFWLPLVLLIIASWGRSQKNIRKSQGLLVLLSDNKLQW
KKHEWQIIRRPWLCRYGVLITAQSFYNQKKIRLWVASDGMPQDEWRNINQLLLQYPDI

Download         Length: 417 bp

>T89216 NZ_CP024901:c4188727-4188311 [Photorhabdus laumondii subsp. laumondii]
GTGGTCCTGTGGAAGTGTGATCTCAGGGTATCTTGGCATACCCAGCTAATTTCTACCTGTGTTCATGGTGCAATAGCGCT
TATCGTACTATTTGCTCCGTGGCCTGCGGATGACGCTATTTTCTGGATTTTCTGGCTTCCTTTGGTACTGTTGATTATTG
CCAGTTGGGGGCGTAGCCAGAAAAATATCCGTAAATCTCAAGGGCTTTTAGTTCTTCTCAGTGATAATAAGTTGCAATGG
AAGAAGCATGAGTGGCAAATTATCCGGCGGCCGTGGTTGTGTCGTTATGGCGTATTAATTACGGCTCAATCTTTTTATAA
CCAGAAAAAAATCCGTTTATGGGTCGCATCCGATGGTATGCCACAGGATGAATGGAGGAATATTAATCAACTGTTGTTGC
AATATCCTGATATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10645.25 Da        Isoelectric Point: 5.7258

>AT89216 WP_011147735.1 NZ_CP024901:c4188974-4188708 [Photorhabdus laumondii subsp. laumondii]
MDIDNKARIHWACRRGMRELDISIMPFFKYEYDSLSDDDKRLFIRLLACADPDLFNWLMNHGRPEDEELFRMIKLIQNRN
KDRGPVEV

Download         Length: 267 bp

>AT89216 NZ_CP024901:c4188974-4188708 [Photorhabdus laumondii subsp. laumondii]
ATGGATATTGATAATAAAGCGCGTATTCATTGGGCATGTCGGCGTGGAATGCGTGAGCTGGATATTTCAATTATGCCGTT
TTTTAAGTATGAATATGACTCACTCAGTGATGATGATAAACGACTTTTTATTCGCTTACTTGCATGTGCTGATCCTGATC
TATTCAACTGGCTAATGAATCATGGGCGTCCAGAAGATGAAGAGTTATTTCGCATGATTAAACTTATTCAGAATAGAAAT
AAAGATCGTGGTCCTGTGGAAGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JK22

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JKF1

References