Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3561545..3562200 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name vapC Uniprot ID Q7N2L9
Locus tag PluTT01m_RS15780 Protein ID WP_011147274.1
Coordinates 3561545..3561964 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q7N2L8
Locus tag PluTT01m_RS15785 Protein ID WP_011147275.1
Coordinates 3561961..3562200 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS15755 3556563..3558854 + 2292 WP_011147269.1 ribonucleoside-diphosphate reductase subunit alpha -
PluTT01m_RS15760 3558867..3559997 + 1131 WP_011147270.1 ribonucleotide-diphosphate reductase subunit beta -
PluTT01m_RS15765 3559997..3560263 + 267 WP_011147271.1 2Fe-2S ferredoxin-like protein -
PluTT01m_RS15770 3560385..3560765 - 381 WP_011147272.1 type II toxin-antitoxin system YafO family toxin -
PluTT01m_RS15775 3560765..3561385 - 621 WP_041380171.1 hypothetical protein -
PluTT01m_RS15780 3561545..3561964 - 420 WP_011147274.1 type II toxin-antitoxin system VapC family toxin Toxin
PluTT01m_RS15785 3561961..3562200 - 240 WP_011147275.1 Arc family DNA-binding protein Antitoxin
PluTT01m_RS15790 3562530..3563543 + 1014 WP_041380173.1 Gfo/Idh/MocA family oxidoreductase -
PluTT01m_RS15795 3563785..3564291 - 507 WP_011147276.1 CdiI family contact-dependent growth inhibition immunity protein -
PluTT01m_RS15800 3564455..3564961 - 507 WP_011147277.1 CdiI family contact-dependent growth inhibition immunity protein -
PluTT01m_RS15805 3565125..3565625 - 501 WP_011147278.1 CdiI family contact-dependent growth inhibition immunity protein -
PluTT01m_RS15810 3565625..3565969 - 345 WP_011147279.1 hypothetical protein -
PluTT01m_RS15815 3566196..3566732 - 537 WP_011147280.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(5-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14785.05 Da        Isoelectric Point: 6.4726

>T89213 WP_011147274.1 NZ_CP024901:c3561964-3561545 [Photorhabdus laumondii subsp. laumondii]
MILLDTNVVSEPLRLSGHPAVVAWIDEQNVETLYLAAISLAELRFGVAALSNGKRKDTLHRNLERSVVPLFTGRILPFDA
AASEAYAEIMARAKSEGKAIGKADGYIAAIAAANGLIVATRDISPFEAAGLTVINPWKG

Download         Length: 420 bp

>T89213 NZ_CP024901:c3561964-3561545 [Photorhabdus laumondii subsp. laumondii]
ATGATACTGCTAGATACGAACGTGGTTTCCGAGCCACTGCGGCTCAGCGGCCACCCCGCTGTGGTTGCCTGGATAGATGA
ACAGAATGTCGAGACGCTTTACTTGGCAGCGATCAGCTTGGCTGAGCTTCGCTTTGGGGTTGCAGCGCTGTCCAATGGTA
AGCGCAAAGATACCCTGCATAGAAACCTAGAGCGGAGTGTTGTTCCTTTATTTACCGGTCGTATCTTGCCATTCGATGCG
GCCGCTTCGGAAGCTTATGCCGAGATCATGGCGCGAGCGAAGAGCGAGGGGAAAGCCATTGGGAAGGCTGACGGGTATAT
TGCGGCTATTGCAGCGGCGAATGGGCTGATTGTTGCAACCCGCGACATATCACCTTTTGAAGCTGCCGGGCTTACTGTTA
TCAACCCTTGGAAGGGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8776.01 Da        Isoelectric Point: 5.7268

>AT89213 WP_011147275.1 NZ_CP024901:c3562200-3561961 [Photorhabdus laumondii subsp. laumondii]
MPSITVRNVPDEVHRALRVRAATHGRSAEAEIRFILENAVQPEGRIKLGSLLAKIGREAEGVDLEIERDKTPAEPMSFE

Download         Length: 240 bp

>AT89213 NZ_CP024901:c3562200-3561961 [Photorhabdus laumondii subsp. laumondii]
ATGCCATCCATTACTGTCAGAAATGTACCGGACGAAGTGCATCGTGCCTTGCGGGTACGCGCAGCCACACATGGCCGTAG
TGCTGAGGCCGAAATCCGGTTTATTCTGGAAAACGCCGTACAACCGGAGGGGCGCATCAAGCTGGGTTCCTTGCTGGCAA
AAATCGGCCGCGAGGCGGAGGGCGTCGATCTTGAGATCGAGCGTGATAAGACACCTGCTGAGCCGATGAGTTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JKK2

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JKY2

References