Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 2785139..2785719 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name vapC Uniprot ID Q7N4G9
Locus tag PluTT01m_RS12220 Protein ID WP_011146604.1
Coordinates 2785139..2785516 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q7N4G8
Locus tag PluTT01m_RS12225 Protein ID WP_011146605.1
Coordinates 2785516..2785719 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS12195 2780294..2781841 + 1548 WP_011146597.1 YdgA family protein -
PluTT01m_RS12200 2781919..2782920 + 1002 WP_011146598.1 adenosine deaminase -
PluTT01m_RS27110 2783090..2783203 + 114 WP_173362526.1 hypothetical protein -
PluTT01m_RS12205 2783219..2783635 + 417 WP_165828667.1 plasmid pRiA4b ORF-3 family protein -
PluTT01m_RS12210 2783709..2783831 - 123 Protein_2322 peptidase -
PluTT01m_RS12215 2783921..2784322 - 402 WP_154097930.1 type II toxin-antitoxin system PemK/MazF family toxin -
PluTT01m_RS25935 2784255..2784512 - 258 WP_011146602.1 antitoxin -
PluTT01m_RS12220 2785139..2785516 - 378 WP_011146604.1 type II toxin-antitoxin system VapC family toxin Toxin
PluTT01m_RS12225 2785516..2785719 - 204 WP_011146605.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PluTT01m_RS12230 2785818..2785978 + 161 Protein_2327 IS5/IS1182 family transposase -
PluTT01m_RS12235 2786058..2786522 + 465 WP_011146606.1 hypothetical protein -
PluTT01m_RS12240 2786540..2786839 + 300 WP_011146607.1 type II toxin-antitoxin system RelE/ParE family toxin -
PluTT01m_RS12245 2787356..2787637 - 282 WP_011146608.1 hypothetical protein -
PluTT01m_RS12250 2788073..2789044 - 972 WP_011146609.1 bile acid:sodium symporter -
PluTT01m_RS12255 2789253..2790290 - 1038 WP_011146610.1 oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13907.45 Da        Isoelectric Point: 7.3226

>T89210 WP_011146604.1 NZ_CP024901:c2785516-2785139 [Photorhabdus laumondii subsp. laumondii]
MTILVDTSVWIDHFKNRNDGLIQLLSRDLVLIHPMILAEIACGTPLAPRLRTLGDLGLLPQSHQATIIEVMAFIENEKLY
GLGCGLVDITLLASTLITPGARLWTLDKRLEKLAKRLNASYQPIH

Download         Length: 378 bp

>T89210 NZ_CP024901:c2785516-2785139 [Photorhabdus laumondii subsp. laumondii]
ATGACTATTTTAGTAGATACGTCCGTCTGGATTGACCATTTCAAAAACAGGAATGACGGATTGATCCAGTTGTTAAGCCG
GGATCTGGTTCTGATTCATCCGATGATACTGGCTGAAATAGCCTGTGGTACTCCTCTGGCACCAAGACTGCGAACGCTTG
GAGATCTGGGGCTGTTACCACAGAGTCATCAGGCCACTATCATCGAGGTAATGGCATTCATTGAAAACGAAAAGTTGTAC
GGCCTCGGATGTGGTCTGGTTGATATTACATTGCTGGCATCAACCTTGATAACACCAGGGGCAAGGCTTTGGACGCTGGA
TAAACGACTTGAGAAGTTGGCTAAACGTCTTAATGCGAGTTATCAGCCGATTCATTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7424.51 Da        Isoelectric Point: 6.2644

>AT89210 WP_011146605.1 NZ_CP024901:c2785719-2785516 [Photorhabdus laumondii subsp. laumondii]
MRTTVTIDDALYAQALEMADPGMDKADIFREAVKTFVRVQAAKRLASLGSTSPDMQIVPRRREEPSA

Download         Length: 204 bp

>AT89210 NZ_CP024901:c2785719-2785516 [Photorhabdus laumondii subsp. laumondii]
ATGCGAACTACTGTCACGATTGATGATGCGTTGTATGCACAGGCACTAGAAATGGCCGATCCTGGCATGGATAAGGCTGA
TATTTTCCGTGAAGCGGTGAAAACGTTTGTTCGGGTGCAGGCAGCAAAAAGACTGGCTTCGCTCGGCAGCACATCACCTG
ATATGCAGATAGTTCCCCGTCGCCGGGAGGAGCCATCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JG72

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JFL4

References