Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2706247..2706797 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name parE Uniprot ID Q7N4M0
Locus tag PluTT01m_RS11935 Protein ID WP_011146553.1
Coordinates 2706507..2706797 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N4M1
Locus tag PluTT01m_RS11930 Protein ID WP_011146552.1
Coordinates 2706247..2706519 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS11905 2701463..2702944 - 1482 WP_011146548.1 type VI secretion system contractile sheath large subunit -
PluTT01m_RS11910 2702952..2703503 - 552 WP_011146549.1 type VI secretion system contractile sheath small subunit -
PluTT01m_RS11915 2704228..2704482 + 255 WP_011146550.1 hypothetical protein -
PluTT01m_RS11920 2704727..2705602 - 876 WP_011146551.1 phage tail protein -
PluTT01m_RS11930 2706247..2706519 + 273 WP_011146552.1 CopG family ribbon-helix-helix protein Antitoxin
PluTT01m_RS11935 2706507..2706797 + 291 WP_011146553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluTT01m_RS11945 2707022..2707198 + 177 Protein_2268 IS1595 family transposase -
PluTT01m_RS11950 2707235..2707513 - 279 WP_011146554.1 putative addiction module antidote protein -
PluTT01m_RS11955 2707510..2707812 - 303 WP_011146555.1 type II toxin-antitoxin system RelE/ParE family toxin -
PluTT01m_RS11960 2707910..2708050 + 141 WP_082302859.1 recombinase family protein -
PluTT01m_RS27105 2708043..2708231 - 189 Protein_2272 helix-turn-helix domain-containing protein -
PluTT01m_RS11970 2708221..2708310 - 90 Protein_2273 class A beta-lactamase -
PluTT01m_RS11975 2709005..2710858 + 1854 WP_011146556.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10867.56 Da        Isoelectric Point: 10.0918

>T89207 WP_011146553.1 NZ_CP024901:2706507-2706797 [Photorhabdus laumondii subsp. laumondii]
MPRLIWSPPALADIQRLYGFLAKKDKDTARRAIKTIRAGVKMLARQPEAGRPADDMDPAFREWLIDFGSSGYIALYRIEG
ETATIFAVRHQKEAGY

Download         Length: 291 bp

>T89207 NZ_CP024901:2706507-2706797 [Photorhabdus laumondii subsp. laumondii]
ATGCCACGTTTGATTTGGTCTCCGCCTGCTCTCGCTGATATACAGCGGCTCTATGGTTTTCTTGCTAAAAAAGACAAAGA
CACTGCTCGTCGAGCTATTAAAACAATACGTGCTGGCGTGAAAATGCTGGCACGTCAGCCTGAAGCAGGACGCCCTGCTG
ACGATATGGATCCGGCATTCCGAGAATGGCTTATTGATTTTGGAAGTAGTGGCTATATCGCCTTGTATCGGATTGAGGGT
GAAACAGCAACAATTTTTGCTGTACGGCATCAAAAAGAGGCCGGATATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10654.87 Da        Isoelectric Point: 4.6704

>AT89207 WP_011146552.1 NZ_CP024901:2706247-2706519 [Photorhabdus laumondii subsp. laumondii]
MATSVKLDDNLKSRIQYLAEVRHRSAHWIMREAIRDYVEREEKRESFKQDALRAWEAYQENGLHLTLEEADDWLAKLEAG
EDAELPECHV

Download         Length: 273 bp

>AT89207 NZ_CP024901:2706247-2706519 [Photorhabdus laumondii subsp. laumondii]
ATGGCAACCTCAGTAAAACTTGACGATAACTTGAAAAGCCGGATCCAGTATTTGGCAGAAGTGCGACATCGTTCAGCTCA
TTGGATAATGCGTGAAGCTATACGTGACTATGTAGAGCGCGAGGAAAAGCGTGAATCTTTCAAACAGGATGCATTGCGTG
CTTGGGAAGCGTATCAAGAGAATGGACTACACCTGACGCTTGAAGAAGCGGACGACTGGTTAGCTAAGCTCGAAGCAGGA
GAAGATGCGGAGTTACCTGAATGCCACGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JTC2

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JNK5

References