Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 2489210..2489741 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name relE Uniprot ID Q7N553
Locus tag PluTT01m_RS10920 Protein ID WP_011146359.1
Coordinates 2489451..2489741 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N554
Locus tag PluTT01m_RS10915 Protein ID WP_011146358.1
Coordinates 2489210..2489461 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS10880 2484709..2485272 + 564 WP_011146352.1 VOC family protein -
PluTT01m_RS10885 2485288..2485602 - 315 WP_011146353.1 type II toxin-antitoxin system MqsA family antitoxin -
PluTT01m_RS10890 2485603..2485938 - 336 WP_011146354.1 hypothetical protein -
PluTT01m_RS10895 2485993..2486151 + 159 Protein_2060 VOC family protein -
PluTT01m_RS10900 2486289..2487035 + 747 WP_011146355.1 copper homeostasis protein CutC -
PluTT01m_RS10905 2487211..2488182 - 972 WP_011146356.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
PluTT01m_RS10910 2488179..2488937 - 759 WP_011146357.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
PluTT01m_RS10915 2489210..2489461 + 252 WP_011146358.1 plasmid stabilization protein Antitoxin
PluTT01m_RS10920 2489451..2489741 + 291 WP_011146359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluTT01m_RS10925 2489868..2490263 - 396 WP_011146360.1 MAPEG family protein -
PluTT01m_RS10930 2490540..2492312 + 1773 WP_011146361.1 aspartate--tRNA ligase -
PluTT01m_RS10935 2492312..2492749 + 438 WP_011146362.1 dihydroneopterin triphosphate diphosphatase -
PluTT01m_RS10940 2492779..2493522 + 744 WP_011146363.1 YebC/PmpR family DNA-binding transcriptional regulator -
PluTT01m_RS10945 2493754..2494275 + 522 WP_011146364.1 crossover junction endodeoxyribonuclease RuvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11169.14 Da        Isoelectric Point: 11.2253

>T89203 WP_011146359.1 NZ_CP024901:2489451-2489741 [Photorhabdus laumondii subsp. laumondii]
MIYSLQFEKRALKEWKKLGHPIKEQLKRKLAERLENPHVPSARLSGRSNRYKIKLRSSGNRLVYEVNDNKIILLVIAIGK
RGKRVGDAVYTLANER

Download         Length: 291 bp

>T89203 NZ_CP024901:2489451-2489741 [Photorhabdus laumondii subsp. laumondii]
ATGATCTATAGTCTGCAATTTGAAAAGCGGGCCTTAAAAGAGTGGAAGAAGTTAGGTCATCCAATTAAGGAGCAGCTAAA
GAGAAAATTGGCTGAACGCTTAGAAAACCCTCATGTGCCGTCAGCAAGATTAAGTGGGCGATCGAACCGATACAAAATTA
AATTGCGGTCTTCTGGCAACCGCTTGGTTTATGAAGTGAATGACAATAAGATTATCTTGCTGGTAATTGCTATTGGTAAA
CGTGGTAAACGGGTCGGAGATGCGGTTTATACCCTCGCCAATGAGAGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.42 Da        Isoelectric Point: 3.8209

>AT89203 WP_011146358.1 NZ_CP024901:2489210-2489461 [Photorhabdus laumondii subsp. laumondii]
MAYQILTNLAASITDLKRNPMGTYLQGEGEAVAILNRNEPAFYCVPPELFAYYQELAEDAALNKIADERLENAEFVSVNL
DDL

Download         Length: 252 bp

>AT89203 NZ_CP024901:2489210-2489461 [Photorhabdus laumondii subsp. laumondii]
ATGGCATATCAAATCTTAACAAATTTAGCGGCAAGTATTACCGATTTGAAACGTAACCCAATGGGGACATATTTGCAGGG
GGAAGGTGAAGCGGTCGCAATCCTGAATCGGAATGAACCTGCATTTTATTGTGTGCCTCCTGAATTATTCGCCTACTATC
AGGAGCTAGCAGAGGATGCCGCACTAAACAAAATTGCAGATGAACGTTTAGAAAATGCTGAATTTGTTAGTGTGAACCTG
GATGATCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JHY5

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JPX9

References