Detailed information of TA system TA089197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 990570..991353
• Replicon: chromosome
• Accession: NZ_CP024901
• Organism: Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: Q7N879
• Locus tag: PluTT01m_RS04445
• Protein ID: WP_011145230.1
• Coordinates: 990853..991353 (+)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: PluTT01m_RS04440
• Protein ID: WP_011145229.1
• Coordinates: 990570..990848 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluTT01m_RS04415	985887..987053	-	1167	WP_011145224.1	cupin domain-containing protein	-
PluTT01m_RS04420	987213..987629	-	417	WP_192880152.1	hypothetical protein	-
PluTT01m_RS04430	989171..989434	+	264	WP_011145227.1	helix-turn-helix domain-containing protein	-
PluTT01m_RS04435	989804..990349	+	546	WP_011145228.1	hypoxanthine phosphoribosyltransferase	-
PluTT01m_RS04440	990570..990848	+	279	WP_011145229.1	DUF1778 domain-containing protein	Antitoxin
PluTT01m_RS04445	990853..991353	+	501	WP_011145230.1	GNAT family N-acetyltransferase	Toxin
PluTT01m_RS04450	991508..992047	+	540	WP_041379935.1	SocA family protein	-
PluTT01m_RS04455	992382..992918	+	537	WP_011145232.1	hypoxanthine phosphoribosyltransferase	-
PluTT01m_RS04460	993018..993296	-	279	WP_011145233.1	HigA family addiction module antidote protein	-
PluTT01m_RS04465	993307..993588	-	282	WP_011145234.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PluTT01m_RS04475	995108..995761	-	654	WP_011145235.1	carbonate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-142)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-92)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 18532.23 Da
• Isoelectric Point: 9.2491

>T89197 WP_011145230.1 NZ_CP024901:990853-991353 [Photorhabdus laumondii subsp. laumondii]
MINDPTLLTDDHNLNSFTSGIDTLDNWLTDRALKNQKENASRTYVVSEDRDVIAYYSLATGSIMSEEAISKFKRNMPNPI
PTIILGRLAVDKRYQGRGFGRYLVRDASIRVAQAADLVGVRGLIVHAISENAKAFYKSVGFSDSLLNPMTLMITLKDLKT
VFKITD

Nucleotide

• Length: 501 bp

>T89197 NZ_CP024901:990853-991353 [Photorhabdus laumondii subsp. laumondii]
ATGATTAATGATCCAACCTTGTTAACAGATGATCACAATTTAAATAGTTTTACTTCAGGAATTGATACCCTAGACAACTG
GTTAACAGACAGAGCATTAAAAAATCAAAAAGAGAATGCTTCACGAACCTATGTTGTAAGCGAAGACAGAGATGTTATTG
CTTATTATTCGTTAGCGACCGGCTCAATTATGTCAGAAGAGGCGATAAGCAAGTTTAAGCGTAATATGCCAAATCCTATT
CCGACGATTATTTTGGGTCGCTTAGCTGTTGATAAGCGTTATCAAGGAAGAGGGTTTGGTCGCTATTTAGTTAGAGATGC
TTCCATACGTGTCGCTCAAGCGGCAGATTTGGTGGGTGTTAGGGGGTTGATTGTCCATGCTATCTCGGAGAATGCTAAGG
CATTTTATAAGTCTGTGGGTTTTAGTGATTCGCTTTTAAATCCAATGACGTTAATGATCACGCTAAAGGATTTAAAAACG
GTTTTTAAAATAACAGATTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10637.37 Da
• Isoelectric Point: 10.2880

>AT89197 WP_011145229.1 NZ_CP024901:990570-990848 [Photorhabdus laumondii subsp. laumondii]
MNVISENRKNKTLNLRIRQEDRDLIDRAAKVKGKTVTEYVLDTIKRDAENTLLEHSFMIVSPEIFNAFIAKLDAPAVPNE
RLIKTANMKKPW

Nucleotide

• Length: 279 bp

>AT89197 NZ_CP024901:990570-990848 [Photorhabdus laumondii subsp. laumondii]
ATGAACGTAATAAGTGAGAATCGTAAAAATAAGACACTCAACTTGAGGATTAGGCAAGAGGATCGGGATTTAATAGATAG
AGCAGCAAAAGTGAAGGGAAAAACCGTTACTGAATATGTCCTTGATACAATCAAACGTGATGCTGAAAACACGTTATTGG
AACATTCATTTATGATTGTATCTCCAGAAATTTTTAATGCTTTTATTGCTAAACTTGATGCTCCGGCTGTTCCAAATGAG
CGTCTTATCAAAACGGCAAATATGAAAAAACCGTGGTGA

Structures

Toxin

• AlphaFold DB: A0A6L9JXS3