Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 271539..272073 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name relE Uniprot ID Q7N9Q9
Locus tag PluTT01m_RS01310 Protein ID WP_011144654.1
Coordinates 271783..272073 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N9R0
Locus tag PluTT01m_RS01305 Protein ID WP_011144653.1
Coordinates 271539..271793 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS01280 266883..267074 + 192 Protein_242 hypothetical protein -
PluTT01m_RS01285 267751..268494 + 744 WP_011144649.1 class I SAM-dependent methyltransferase -
PluTT01m_RS01290 268770..269177 - 408 WP_011144650.1 type II toxin-antitoxin system RelE/ParE family toxin -
PluTT01m_RS01295 269180..269449 - 270 WP_011144651.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PluTT01m_RS01300 270365..271132 + 768 WP_011144652.1 Fic family protein -
PluTT01m_RS01305 271539..271793 + 255 WP_011144653.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PluTT01m_RS01310 271783..272073 + 291 WP_011144654.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluTT01m_RS01320 273062..273322 - 261 WP_011144656.1 hypothetical protein -
PluTT01m_RS01325 273416..273694 - 279 WP_011144657.1 hypothetical protein -
PluTT01m_RS01330 274350..276431 - 2082 WP_011144658.1 ATP-dependent DNA helicase RecG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11349.32 Da        Isoelectric Point: 9.9557

>T89195 WP_011144654.1 NZ_CP024901:271783-272073 [Photorhabdus laumondii subsp. laumondii]
MIFNIDFDERALKEWYKLDQSIRDQFKKKLRKLQNNPYIDSARLHGNLAGCFKIKLRSSGFRLVYQVIEEEIVILVIAVG
KREDAKTYEIACKRIV

Download         Length: 291 bp

>T89195 NZ_CP024901:271783-272073 [Photorhabdus laumondii subsp. laumondii]
ATGATATTTAATATCGATTTCGACGAACGAGCCCTGAAAGAGTGGTACAAACTGGATCAGAGCATACGCGACCAATTTAA
AAAGAAGCTACGGAAGTTACAGAACAATCCCTATATTGATTCAGCCAGATTACACGGTAATCTGGCTGGCTGCTTTAAAA
TTAAACTCCGTTCTTCAGGCTTTCGTCTGGTTTACCAAGTGATAGAAGAAGAGATCGTAATATTGGTGATCGCTGTTGGT
AAACGGGAAGATGCGAAAACTTATGAAATAGCTTGTAAACGAATTGTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9774.19 Da        Isoelectric Point: 4.8485

>AT89195 WP_011144653.1 NZ_CP024901:271539-271793 [Photorhabdus laumondii subsp. laumondii]
MSTIQIRVDEELKKSAYQTFEKLNLSPSDALRLFLRYVVENEKLPFTEVSVMVADHDEDADILAVVRDRLKNPARRIRVN
LDDI

Download         Length: 255 bp

>AT89195 NZ_CP024901:271539-271793 [Photorhabdus laumondii subsp. laumondii]
ATGAGTACTATTCAGATCAGAGTTGATGAAGAACTTAAAAAAAGTGCGTATCAGACATTTGAGAAACTGAACTTATCGCC
ATCTGATGCGCTACGTCTCTTTCTGCGATATGTTGTGGAGAATGAAAAGCTGCCGTTCACTGAAGTTTCCGTTATGGTGG
CAGATCATGATGAAGATGCAGACATCTTAGCAGTGGTACGTGACCGTCTTAAAAATCCCGCTAGACGTATCAGGGTAAAC
CTTGATGATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JHV9

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JHC8

References