Detailed information of TA system TA089185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4464954..4465480
• Replicon: chromosome
• Accession: NZ_CP024900
• Organism: Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PluDJC_RS19685
• Protein ID: WP_109791823.1
• Coordinates: 4465205..4465480 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6L9JMF5
• Locus tag: PluDJC_RS19680
• Protein ID: WP_036778328.1
• Coordinates: 4464954..4465202 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluDJC_RS19660	4460165..4461538	+	1374	WP_109791821.1	outer membrane channel protein TolC	-
PluDJC_RS19665	4461787..4462200	-	414	WP_011148089.1	DUF2628 domain-containing protein	-
PluDJC_RS19670	4462612..4463316	+	705	WP_011148090.1	DUF1190 family protein	-
PluDJC_RS19675	4463323..4464483	+	1161	WP_109791822.1	glutathionylspermidine synthase family protein	-
PluDJC_RS19680	4464954..4465202	+	249	WP_036778328.1	ribbon-helix-helix domain-containing protein	Antitoxin
PluDJC_RS19685	4465205..4465480	+	276	WP_109791823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PluDJC_RS26420	4465494..4465652	-	159	WP_011148094.1	hypothetical protein	-
PluDJC_RS19690	4465719..4466504	-	786	WP_058589147.1	4,5-DOPA dioxygenase extradiol	-
PluDJC_RS19695	4466699..4467352	-	654	WP_011148096.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
PluDJC_RS19700	4467812..4468102	+	291	WP_058589148.1	accessory factor UbiK family protein	-
PluDJC_RS19705	4468182..4468844	-	663	WP_058589149.1	DUF799 domain-containing protein	-
PluDJC_RS19710	4468841..4469200	-	360	WP_109791824.1	DUF4810 domain-containing protein	-
PluDJC_RS19715	4469222..4469893	-	672	WP_011148100.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-42)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10945.43 Da
• Isoelectric Point: 6.9761

>T89185 WP_109791823.1 NZ_CP024900:4465205-4465480 [Photorhabdus laumondii subsp. laumondii]
MEVYWTLKAQNDLERIYHFACQYSKSHANNVLDHLIISTTDLALQPKIGIPQPRYKPREVRKVLFSDYEVHYEISNDTIY
IVDLWHPRENR

Nucleotide

• Length: 276 bp

>T89185 NZ_CP024900:4465205-4465480 [Photorhabdus laumondii subsp. laumondii]
ATGGAGGTTTATTGGACACTTAAAGCTCAAAATGATTTGGAGCGCATCTATCATTTTGCCTGTCAATACAGTAAATCACA
TGCTAATAATGTGTTAGACCATCTAATTATCAGCACTACAGATCTGGCACTGCAACCTAAGATAGGGATTCCTCAGCCTA
GATATAAGCCCCGCGAGGTACGTAAGGTACTTTTTAGTGATTACGAAGTCCATTACGAGATATCCAACGATACAATTTAC
ATTGTAGACCTTTGGCATCCCCGCGAAAACCGTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9141.62 Da
• Isoelectric Point: 9.9515

>AT89185 WP_036778328.1 NZ_CP024900:4464954-4465202 [Photorhabdus laumondii subsp. laumondii]
MSISAKQTITAQIPIKLATAINDLAKELDRSKSWIIKEALTSMIEEREHRHQMILAGLADVDTGRIVNHSDVINFASKLK
KS

Nucleotide

• Length: 249 bp

>AT89185 NZ_CP024900:4464954-4465202 [Photorhabdus laumondii subsp. laumondii]
ATGTCCATATCAGCAAAACAGACAATTACCGCACAGATACCGATCAAACTAGCTACAGCCATAAACGATTTAGCCAAAGA
GTTAGACCGCTCAAAATCGTGGATCATTAAAGAGGCTCTTACCTCAATGATTGAGGAACGTGAACATCGCCACCAAATGA
TTTTGGCTGGCCTCGCGGATGTCGATACAGGCCGTATTGTGAATCATTCAGATGTTATTAATTTTGCATCCAAGCTGAAA
AAATCATAA

Structures

Antitoxin

• AlphaFold DB: A0A6L9JMF5