Detailed information of TA system TA089176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2742525..2743438
• Replicon: chromosome
• Accession: NZ_CP024900
• Organism: Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PluDJC_RS12520
• Protein ID: WP_113049466.1
• Coordinates: 2742968..2743438 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q7N4I0
• Locus tag: PluDJC_RS12515
• Protein ID: WP_011146593.1
• Coordinates: 2742525..2742971 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluDJC_RS12495	2737830..2738429	+	600	WP_011146588.1	lytic polysaccharide monooxygenase	-
PluDJC_RS12500	2738650..2739762	-	1113	WP_113049469.1	class II histone deacetylase	-
PluDJC_RS12505	2740244..2740711	-	468	WP_113049468.1	hypothetical protein	-
PluDJC_RS12510	2741526..2742452	+	927	WP_113049467.1	DNA replication terminus site-binding protein	-
PluDJC_RS12515	2742525..2742971	+	447	WP_011146593.1	type II toxin-antitoxin system antitoxin Xre	Antitoxin
PluDJC_RS12520	2742968..2743438	+	471	WP_113049466.1	type II toxin-antitoxin system NAD+ phosphorylase toxin Res	Toxin
PluDJC_RS12525	2743506..2744900	-	1395	WP_011146595.1	class II fumarate hydratase	-
PluDJC_RS12530	2745205..2746377	+	1173	WP_113049465.1	mannose-6-phosphate isomerase	-
PluDJC_RS12535	2746517..2748049	+	1533	WP_113049464.1	YdgA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre (15-148)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17385.97 Da
• Isoelectric Point: 5.1801

>T89176 WP_113049466.1 NZ_CP024900:2742968-2743438 [Photorhabdus laumondii subsp. laumondii]
VILYRLTRSKYVESAWSGTGAKLYSGRWHNIGRPAVYVATSVSLAVLEVLVHVGDDELLTDFALLSIDIPENQIDILDID
TLPSDWNAPVPSTCTMEIGSEWFEVSHSIGLVVPSAIVPYENNIILNPMAKDFHKYINTVKRLDFGIDSRLVKAKK

Nucleotide

• Length: 471 bp

>T89176 NZ_CP024900:2742968-2743438 [Photorhabdus laumondii subsp. laumondii]
GTGATCTTATACCGACTTACCCGTTCAAAATATGTCGAATCAGCATGGAGTGGTACAGGAGCAAAGTTATATAGTGGCCG
TTGGCACAATATAGGAAGACCCGCAGTTTATGTAGCCACTTCAGTTTCTCTTGCTGTGCTAGAAGTACTTGTTCATGTCG
GAGATGATGAACTTCTCACTGATTTTGCTTTGTTAAGTATCGACATCCCTGAAAACCAAATTGATATTTTAGACATTGAT
ACATTACCTTCTGATTGGAATGCTCCCGTACCTTCTACTTGCACAATGGAAATAGGCAGTGAATGGTTCGAGGTTAGTCA
TTCTATTGGCCTGGTAGTTCCCTCTGCCATTGTCCCCTACGAAAATAACATCATTTTGAATCCTATGGCGAAAGATTTTC
ATAAATATATAAACACGGTTAAACGCTTGGATTTTGGCATTGATTCCCGTTTAGTAAAGGCAAAAAAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16466.92 Da
• Isoelectric Point: 10.4604

>AT89176 WP_011146593.1 NZ_CP024900:2742525-2742971 [Photorhabdus laumondii subsp. laumondii]
MRVFTPSHKVQSNPLWRTVGFPSSSGPHLNAILNEGLPVTIVDKIQNWSTFGKGDILRIAGIQIRSYSRRCSGKGKFTAD
ESQRIARFVRVMDHAVDLFNGDKDKAAQWMKRPIRGLGYVTPESMLDTESGALDVMNLIGRIEHGIVS

Nucleotide

• Length: 447 bp

>AT89176 NZ_CP024900:2742525-2742971 [Photorhabdus laumondii subsp. laumondii]
ATGCGAGTTTTTACACCAAGCCACAAAGTCCAGAGTAACCCACTTTGGCGAACAGTTGGTTTCCCATCAAGCAGTGGGCC
ACATTTGAATGCAATATTAAATGAAGGGTTACCAGTCACTATAGTTGATAAAATACAAAACTGGTCAACGTTCGGTAAAG
GGGATATTTTGCGGATTGCAGGTATCCAAATACGCAGTTATTCAAGACGCTGTTCAGGTAAAGGTAAATTTACTGCTGAT
GAAAGTCAGCGCATTGCTCGGTTTGTACGTGTCATGGACCATGCTGTAGATTTATTTAATGGTGACAAAGATAAAGCAGC
TCAATGGATGAAGCGACCTATCCGGGGTTTAGGATACGTAACGCCTGAATCAATGCTCGATACAGAAAGTGGAGCGCTAG
ATGTCATGAATCTCATCGGCAGGATTGAACACGGAATTGTATCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6L9JG75