Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2644576..2645122 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name ccdB Uniprot ID Q7N4P3
Locus tag PluDJC_RS12135 Protein ID WP_011146528.1
Coordinates 2644817..2645122 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7N4P4
Locus tag PluDJC_RS12130 Protein ID WP_011146527.1
Coordinates 2644576..2644815 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS12110 2640019..2641203 - 1185 WP_109791559.1 DNA-binding transcriptional regulator -
PluDJC_RS12115 2641511..2642830 + 1320 WP_011146524.1 xylose isomerase -
PluDJC_RS12120 2643250..2643822 + 573 WP_011146525.1 hypothetical protein -
PluDJC_RS12125 2644114..2644488 + 375 WP_041380079.1 VOC family protein -
PluDJC_RS12130 2644576..2644815 + 240 WP_011146527.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PluDJC_RS12135 2644817..2645122 + 306 WP_011146528.1 CcdB family protein Toxin
PluDJC_RS12140 2645241..2645333 - 93 WP_071824109.1 type II toxin-antitoxin system YoeB family toxin -
PluDJC_RS12145 2645393..2645647 - 255 WP_011146529.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
PluDJC_RS12150 2645703..2646116 - 414 WP_113049478.1 Exc2 family lipoprotein -
PluDJC_RS12155 2646168..2646368 - 201 WP_011146531.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11682.71 Da        Isoelectric Point: 5.0479

>T89172 WP_011146528.1 NZ_CP024900:2644817-2645122 [Photorhabdus laumondii subsp. laumondii]
MQYVVYRNIGNSAYPYLLDVQSDIIDMLNTRLMIPLFLKENFKGKVPIRLCPILTIEESDYIVMTHEMASIRVSMIGNEV
IDVTSHRKQIKDALDFLIDGF

Download         Length: 306 bp

>T89172 NZ_CP024900:2644817-2645122 [Photorhabdus laumondii subsp. laumondii]
ATGCAGTATGTTGTTTATCGCAATATTGGCAATTCTGCTTACCCATATCTTCTTGACGTACAGAGTGACATTATTGATAT
GTTGAATACAAGATTAATGATACCCCTGTTTCTGAAAGAAAATTTTAAAGGCAAAGTTCCTATAAGATTATGTCCAATAT
TGACAATTGAGGAGAGTGACTACATCGTCATGACTCATGAAATGGCAAGTATCAGAGTATCTATGATCGGTAATGAAGTT
ATTGATGTCACATCCCACCGGAAACAAATTAAAGATGCTTTGGATTTTCTCATTGATGGATTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8997.44 Da        Isoelectric Point: 10.3135

>AT89172 WP_011146527.1 NZ_CP024900:2644576-2644815 [Photorhabdus laumondii subsp. laumondii]
MPATQIRLKKTVSVTVAPELYQQARQVGLNLSAVLTKALISELKAVESERWKRENKAGMEELNRITNEHGLLSDKYRVF

Download         Length: 240 bp

>AT89172 NZ_CP024900:2644576-2644815 [Photorhabdus laumondii subsp. laumondii]
ATGCCAGCAACACAAATCAGATTAAAGAAAACAGTGAGCGTGACCGTTGCACCTGAACTGTATCAACAAGCGAGACAGGT
AGGGCTTAACTTATCAGCAGTGCTGACTAAAGCACTAATTTCGGAACTGAAAGCCGTTGAGTCTGAACGCTGGAAACGTG
AGAATAAGGCAGGAATGGAAGAACTTAATCGTATCACTAACGAACACGGTTTACTGTCTGACAAGTACAGGGTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JP64

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JTQ5

References