Detailed information of TA system TA089171

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2632299..2632834
• Replicon: chromosome
• Accession: NZ_CP024900
• Organism: Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PluDJC_RS12065
• Protein ID: WP_109791556.1
• Coordinates: 2632299..2632586 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q7N4Q7
• Locus tag: PluDJC_RS12070
• Protein ID: WP_011146514.1
• Coordinates: 2632583..2632834 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluDJC_RS12055	2627582..2631028	-	3447	WP_109791554.1	molybdopterin-dependent oxidoreductase	-
PluDJC_RS12060	2631232..2632143	-	912	WP_112872313.1	hypothetical protein	-
PluDJC_RS12065	2632299..2632586	-	288	WP_109791556.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PluDJC_RS12070	2632583..2632834	-	252	WP_011146514.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PluDJC_RS12075	2632967..2633926	-	960	WP_113049479.1	hypothetical protein	-
PluDJC_RS12080	2634568..2635028	+	461	Protein_2307	helix-turn-helix domain-containing protein	-
PluDJC_RS12085	2635247..2635537	-	291	WP_011146518.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PluDJC_RS12090	2635534..2635812	-	279	WP_011146519.1	hypothetical protein	-
PluDJC_RS12095	2636116..2636994	-	879	WP_011146520.1	PhzF family phenazine biosynthesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11209.44 Da
• Isoelectric Point: 10.6904

>T89171 WP_109791556.1 NZ_CP024900:c2632586-2632299 [Photorhabdus laumondii subsp. laumondii]
MIYRVKFREDALKEWKRLDKSVQQQFAKKLKKCCVEPHIPSVKLRGMPNCYKIKLRASGFRLVYEVIDNVLIIVVVAVGK
RERSEAYELASKRLR

Nucleotide

• Length: 288 bp

>T89171 NZ_CP024900:c2632586-2632299 [Photorhabdus laumondii subsp. laumondii]
ATGATCTATAGAGTGAAATTCAGGGAAGATGCACTCAAGGAGTGGAAGAGACTTGATAAATCAGTCCAACAACAATTTGC
TAAGAAGCTGAAAAAGTGCTGTGTTGAACCTCATATTCCATCAGTTAAACTTCGAGGCATGCCGAATTGTTACAAAATAA
AATTACGCGCTTCTGGTTTTCGCTTAGTTTATGAGGTCATAGATAATGTGTTGATTATCGTCGTAGTAGCAGTTGGTAAG
CGCGAACGGAGTGAAGCGTATGAGCTAGCAAGTAAGAGACTAAGATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9221.57 Da
• Isoelectric Point: 4.0233

>AT89171 WP_011146514.1 NZ_CP024900:c2632834-2632583 [Photorhabdus laumondii subsp. laumondii]
MANIILSDISASISELKKNPMATLSAGAGYPIAILNRNQPVFYCIPAELYEQILDALDDQELIRLVNERRGQALVDVDLD
NYL

Nucleotide

• Length: 252 bp

>AT89171 NZ_CP024900:c2632834-2632583 [Photorhabdus laumondii subsp. laumondii]
ATGGCCAACATAATTCTGTCAGATATTAGCGCAAGCATTAGTGAACTTAAAAAGAACCCTATGGCGACCCTTAGTGCCGG
GGCTGGATACCCTATTGCGATCCTAAATCGTAACCAACCCGTGTTTTATTGTATTCCTGCGGAGCTCTATGAACAGATAC
TTGATGCTTTGGACGATCAAGAGCTTATTCGACTGGTAAATGAGCGTAGAGGGCAGGCATTGGTTGATGTAGATTTGGAT
AATTATCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A6L9JQJ5