Detailed information of TA system TA089170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2583271..2583812
• Replicon: chromosome
• Accession: NZ_CP024900
• Organism: Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: PluDJC_RS11840
• Protein ID: WP_113049489.1
• Coordinates: 2583271..2583597 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: PluDJC_RS11845
• Protein ID: WP_113049488.1
• Coordinates: 2583594..2583812 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluDJC_RS11835	2578310..2583187	+	4878	WP_113049490.1	hypothetical protein	-
PluDJC_RS11840	2583271..2583597	-	327	WP_113049489.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
PluDJC_RS11845	2583594..2583812	-	219	WP_113049488.1	antitoxin MazE family protein	Antitoxin
PluDJC_RS11850	2584388..2584924	+	537	WP_113049487.1	hypothetical protein	-
PluDJC_RS26310	2584967..2585137	+	171	WP_158536402.1	hypothetical protein	-
PluDJC_RS11855	2585179..2586195	-	1017	WP_011146474.1	hypothetical protein	-
PluDJC_RS11860	2586351..2587625	-	1275	WP_109791547.1	MFS transporter	-
PluDJC_RS11865	2587752..2588666	+	915	WP_011146476.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-103)

Antitoxin

• Antitoxin MazE-like (6-71)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11931.00 Da
• Isoelectric Point: 6.9774

>T89170 WP_113049489.1 NZ_CP024900:c2583597-2583271 [Photorhabdus laumondii subsp. laumondii]
VKRGDLITVALQGAYGKPRPALVIQSDNFDEHPSVTILPVTSTLIDAPLFRVMIEPFPETNLEKPSQVMIDKTMTLPKEK
AGTVFGKLDYTTMQQVDRCLALFLGIAK

Nucleotide

• Length: 327 bp

>T89170 NZ_CP024900:c2583597-2583271 [Photorhabdus laumondii subsp. laumondii]
GTGAAAAGGGGAGACTTGATAACAGTTGCTCTACAAGGGGCTTATGGCAAGCCCCGCCCTGCACTGGTTATCCAATCTGA
CAACTTTGATGAACATCCCAGTGTTACTATTTTGCCCGTGACCTCAACATTAATTGATGCACCACTTTTCCGAGTGATGA
TCGAGCCTTTTCCTGAAACAAATCTTGAAAAACCGTCACAGGTCATGATTGATAAAACCATGACTCTCCCGAAAGAAAAA
GCTGGCACAGTATTTGGTAAACTCGATTACACGACGATGCAGCAAGTGGATCGCTGCTTAGCTTTGTTTTTAGGTATCGC
AAAATAG

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8483.63 Da
• Isoelectric Point: 7.2795

>AT89170 WP_113049488.1 NZ_CP024900:c2583812-2583594 [Photorhabdus laumondii subsp. laumondii]
MNKVADRVKKHRQQLRMSGLRPIQIWVPDTRLPHFKEECRRQSHLAMATQDKETDTLLENAINELADSGDWE

Nucleotide

• Length: 219 bp

>AT89170 NZ_CP024900:c2583812-2583594 [Photorhabdus laumondii subsp. laumondii]
ATGAATAAGGTTGCAGATCGTGTCAAAAAACACAGACAACAGCTCAGGATGTCAGGATTAAGGCCCATTCAAATATGGGT
GCCTGATACACGCCTCCCTCATTTTAAAGAGGAGTGTCGGCGTCAAAGCCATCTGGCTATGGCAACACAGGATAAGGAAA
CGGATACACTATTAGAAAATGCGATAAATGAACTAGCTGATTCAGGAGACTGGGAGTGA