Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 2471079..2471610 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name relE Uniprot ID Q7N553
Locus tag PluDJC_RS11275 Protein ID WP_011146359.1
Coordinates 2471320..2471610 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N554
Locus tag PluDJC_RS11270 Protein ID WP_011146358.1
Coordinates 2471079..2471330 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS11235 2466578..2467141 + 564 WP_109791520.1 VOC family protein -
PluDJC_RS11240 2467157..2467471 - 315 WP_011146353.1 type II toxin-antitoxin system MqsA family antitoxin -
PluDJC_RS11245 2467472..2467807 - 336 WP_011146354.1 hypothetical protein -
PluDJC_RS11250 2467862..2468020 + 159 Protein_2141 VOC family protein -
PluDJC_RS11255 2468158..2468904 + 747 WP_011146355.1 copper homeostasis protein CutC -
PluDJC_RS11260 2469080..2470051 - 972 WP_011146356.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
PluDJC_RS11265 2470048..2470806 - 759 WP_011146357.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
PluDJC_RS11270 2471079..2471330 + 252 WP_011146358.1 plasmid stabilization protein Antitoxin
PluDJC_RS11275 2471320..2471610 + 291 WP_011146359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluDJC_RS11280 2471737..2472132 - 396 WP_011146360.1 MAPEG family protein -
PluDJC_RS11285 2472409..2474181 + 1773 WP_011146361.1 aspartate--tRNA ligase -
PluDJC_RS11290 2474181..2474618 + 438 WP_011146362.1 dihydroneopterin triphosphate diphosphatase -
PluDJC_RS11295 2474648..2475391 + 744 WP_011146363.1 YebC/PmpR family DNA-binding transcriptional regulator -
PluDJC_RS11300 2475623..2476144 + 522 WP_011146364.1 crossover junction endodeoxyribonuclease RuvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11169.14 Da        Isoelectric Point: 11.2253

>T89169 WP_011146359.1 NZ_CP024900:2471320-2471610 [Photorhabdus laumondii subsp. laumondii]
MIYSLQFEKRALKEWKKLGHPIKEQLKRKLAERLENPHVPSARLSGRSNRYKIKLRSSGNRLVYEVNDNKIILLVIAIGK
RGKRVGDAVYTLANER

Download         Length: 291 bp

>T89169 NZ_CP024900:2471320-2471610 [Photorhabdus laumondii subsp. laumondii]
ATGATCTATAGTCTGCAATTTGAAAAGCGGGCCTTAAAAGAGTGGAAGAAGTTAGGTCATCCAATTAAGGAGCAGCTAAA
GAGAAAATTGGCTGAACGCTTAGAAAACCCTCATGTGCCGTCAGCAAGATTAAGTGGGCGATCGAACCGATACAAAATTA
AATTGCGGTCTTCTGGCAACCGCTTGGTTTATGAAGTGAATGACAATAAGATTATCTTGCTGGTAATTGCTATTGGTAAA
CGTGGTAAACGGGTCGGAGATGCGGTTTATACCCTCGCCAATGAGAGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.42 Da        Isoelectric Point: 3.8209

>AT89169 WP_011146358.1 NZ_CP024900:2471079-2471330 [Photorhabdus laumondii subsp. laumondii]
MAYQILTNLAASITDLKRNPMGTYLQGEGEAVAILNRNEPAFYCVPPELFAYYQELAEDAALNKIADERLENAEFVSVNL
DDL

Download         Length: 252 bp

>AT89169 NZ_CP024900:2471079-2471330 [Photorhabdus laumondii subsp. laumondii]
ATGGCATATCAAATCTTAACAAATTTAGCGGCAAGTATTACCGATTTGAAACGTAACCCAATGGGGACATATTTGCAGGG
GGAAGGTGAAGCGGTCGCAATCCTGAATCGGAATGAACCTGCATTTTATTGTGTGCCTCCTGAATTATTCGCCTACTATC
AGGAGCTAGCAGAGGATGCCGCACTAAACAAAATTGCAGATGAACGTTTAGAAAATGCTGAATTTGTTAGTGTGAACCTG
GATGATCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JHY5

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JPX9

References