Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 809788..810416 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name hicA Uniprot ID Q7N8L3
Locus tag PluDJC_RS03635 Protein ID WP_011145083.1
Coordinates 810141..810416 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7N8L4
Locus tag PluDJC_RS03630 Protein ID WP_011145082.1
Coordinates 809788..810144 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS03610 804790..805152 - 363 WP_011145078.1 6-carboxytetrahydropterin synthase QueD -
PluDJC_RS03615 805419..807221 + 1803 WP_011145079.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
PluDJC_RS03620 807221..808951 + 1731 WP_011145080.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
PluDJC_RS03625 808948..809682 + 735 WP_011145081.1 phosphoadenylyl-sulfate reductase -
PluDJC_RS03630 809788..810144 - 357 WP_011145082.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PluDJC_RS03635 810141..810416 - 276 WP_011145083.1 type II toxin-antitoxin system HicA family toxin Toxin
PluDJC_RS03640 810684..812096 + 1413 WP_011145084.1 siroheme synthase CysG -
PluDJC_RS03645 812106..813014 + 909 WP_011145085.1 sulfate adenylyltransferase subunit CysD -
PluDJC_RS03650 813026..814468 + 1443 WP_058589762.1 sulfate adenylyltransferase subunit CysN -
PluDJC_RS03655 814470..815102 + 633 WP_011145087.1 adenylyl-sulfate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(59-111)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10236.91 Da        Isoelectric Point: 9.9633

>T89162 WP_011145083.1 NZ_CP024900:c810416-810141 [Photorhabdus laumondii subsp. laumondii]
MKEQVSMLRKRQKNTLEQIFKMPVPAGIKWSDVESLIIALGGEVKEGKGSRCRLLLNDSIARFHRPHPSPDTDKGAVVSL
REWLESIGVEP

Download         Length: 276 bp

>T89162 NZ_CP024900:c810416-810141 [Photorhabdus laumondii subsp. laumondii]
ATGAAAGAACAGGTTTCAATGCTCAGGAAGAGGCAAAAAAATACGTTGGAGCAGATATTTAAAATGCCTGTTCCTGCGGG
AATTAAGTGGTCTGACGTGGAATCACTCATAATCGCTCTGGGAGGTGAGGTTAAAGAGGGGAAAGGTTCACGTTGCAGGC
TGTTGCTAAACGATAGTATTGCCAGATTTCACCGTCCACATCCCTCACCAGATACTGACAAAGGGGCCGTCGTCAGCCTA
CGAGAATGGTTAGAAAGCATAGGAGTTGAGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13321.23 Da        Isoelectric Point: 5.5798

>AT89162 WP_011145082.1 NZ_CP024900:c810144-809788 [Photorhabdus laumondii subsp. laumondii]
MKMTVQNTMVIAGQQAIISYVPEIGMFRGKFLGLSGYCDFISDSIQGLQDEGKISLHEYLEDCNASGIEPYARQEKIKTF
TLRYPESFGERLHCAAAEHQISVNAFIIETLNERMKHA

Download         Length: 357 bp

>AT89162 NZ_CP024900:c810144-809788 [Photorhabdus laumondii subsp. laumondii]
ATGAAGATGACAGTACAAAATACAATGGTAATAGCCGGACAGCAGGCTATTATTAGCTACGTGCCAGAAATTGGCATGTT
CAGGGGTAAATTTTTAGGGCTGTCTGGTTATTGTGATTTTATCTCTGATAGTATTCAGGGGTTGCAAGATGAGGGTAAAA
TATCTCTACATGAATATCTTGAAGATTGTAACGCATCAGGTATTGAACCTTATGCAAGGCAAGAAAAAATCAAAACATTT
ACTCTGCGCTACCCCGAATCATTTGGAGAGCGATTGCATTGCGCAGCAGCCGAGCATCAGATTTCGGTGAATGCGTTCAT
CATTGAAACTTTAAATGAACGAATGAAACACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JQS1

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JRP4

References