Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 200390..201141 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name ataT Uniprot ID Q7N9X2
Locus tag PluDJC_RS00980 Protein ID WP_011144581.1
Coordinates 200390..200878 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q7N9X1
Locus tag PluDJC_RS00985 Protein ID WP_011144582.1
Coordinates 200869..201141 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS00960 195817..197298 + 1482 WP_011144577.1 fructuronate reductase -
PluDJC_RS00965 197295..198719 + 1425 WP_011144578.1 glucuronate isomerase -
PluDJC_RS00970 198716..199660 + 945 WP_011144579.1 sugar kinase -
PluDJC_RS00975 199678..200307 + 630 WP_041379857.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
PluDJC_RS00980 200390..200878 - 489 WP_011144581.1 GNAT family N-acetyltransferase Toxin
PluDJC_RS00985 200869..201141 - 273 WP_011144582.1 DUF1778 domain-containing protein Antitoxin
PluDJC_RS00990 202277..203782 + 1506 WP_011144584.1 asparagine synthase -
PluDJC_RS00995 203785..204534 + 750 WP_011144585.1 enoyl-CoA hydratase/isomerase family protein -
PluDJC_RS01000 204548..205369 + 822 WP_011144586.1 TauD/TfdA family dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-83)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17983.77 Da        Isoelectric Point: 8.2629

>T89160 WP_011144581.1 NZ_CP024900:c200878-200390 [Photorhabdus laumondii subsp. laumondii]
VGISTPEILTAEHNINDFYCQHETLNEWLSRRALKNNKLGASRTFVICKEGTKDVIGYYCLSAGSINHIESTPSLKRNMP
DPIPVVLLGRLAVDVEYQGKKLGALLLQDAWKRVASTAEQVGISAIIVHALDESARTFYTRLGFVQSPLEPYTLMLPLGK
QK

Download         Length: 489 bp

>T89160 NZ_CP024900:c200878-200390 [Photorhabdus laumondii subsp. laumondii]
GTGGGAATAAGCACACCTGAAATATTAACGGCTGAACATAATATAAATGATTTTTATTGCCAGCATGAAACATTAAACGA
ATGGCTTTCACGCCGGGCTTTAAAAAATAATAAGCTCGGCGCGAGCCGCACATTTGTTATTTGCAAGGAAGGCACAAAAG
ACGTTATCGGTTATTATTGTCTAAGCGCCGGTTCAATTAATCATATTGAATCTACACCATCGCTTAAACGCAATATGCCA
GATCCTATCCCTGTAGTGCTTCTTGGCCGTCTGGCTGTCGATGTGGAATATCAGGGGAAGAAGCTCGGGGCATTGCTTCT
CCAAGATGCTTGGAAGCGTGTCGCCAGCACAGCAGAACAGGTGGGCATTTCAGCTATAATCGTCCACGCACTTGATGAGA
GCGCTCGAACGTTCTATACGCGTCTTGGCTTCGTCCAGTCACCGTTGGAGCCATACACGCTGATGCTTCCATTAGGCAAA
CAGAAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10587.15 Da        Isoelectric Point: 6.7179

>AT89160 WP_011144582.1 NZ_CP024900:c201141-200869 [Photorhabdus laumondii subsp. laumondii]
MRTQPKETPINIRAKAFQRELIDHAANLLSKTRTDFILDAACRAAEDAILDQRHFFVNDEKYHMFMQMLEQPLSDNEGFK
KLMGYKAPWE

Download         Length: 273 bp

>AT89160 NZ_CP024900:c201141-200869 [Photorhabdus laumondii subsp. laumondii]
ATGAGAACACAACCTAAAGAAACCCCGATCAACATCCGGGCGAAAGCCTTCCAGCGGGAGCTTATTGACCATGCAGCAAA
CCTGCTCTCAAAGACCCGAACTGATTTCATCTTGGACGCTGCCTGCCGCGCAGCCGAAGATGCCATACTCGATCAGCGCC
ACTTTTTCGTTAACGACGAAAAATACCATATGTTCATGCAGATGCTGGAGCAACCGCTTTCTGATAATGAAGGTTTTAAA
AAACTGATGGGATATAAAGCACCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JKT6

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JKU1

References