Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4910142..4910812 Replicon chromosome
Accession NZ_CP024894
Organism Amycolatopsis sp. AA4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CU254_RS22760 Protein ID WP_009079712.1
Coordinates 4910142..4910543 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CU254_RS22765 Protein ID WP_009079713.1
Coordinates 4910540..4910812 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU254_RS22745 4905258..4908125 + 2868 WP_009079707.1 alpha/beta fold hydrolase -
CU254_RS22750 4908232..4909170 + 939 WP_009079708.1 ABC transporter permease subunit -
CU254_RS22755 4909176..4909952 + 777 WP_086024898.1 enoyl-CoA hydratase/isomerase family protein -
CU254_RS22760 4910142..4910543 - 402 WP_009079712.1 type II toxin-antitoxin system VapC family toxin Toxin
CU254_RS22765 4910540..4910812 - 273 WP_009079713.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CU254_RS22770 4910841..4912940 - 2100 WP_199786308.1 excinuclease ABC subunit B -
CU254_RS22775 4913082..4914383 - 1302 WP_037714524.1 hypothetical protein -
CU254_RS22780 4914498..4915016 + 519 WP_009079717.1 DUF402 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14231.35 Da        Isoelectric Point: 4.5821

>T89156 WP_009079712.1 NZ_CP024894:c4910543-4910142 [Amycolatopsis sp. AA4]
VIIDSSAIVAVLMEEPLAVPIARAIGGAEECRIGAPTLVETSIVLANKEGERGAALLASFLQRRRFDVLTFGEAHWRTAQ
TAFLRYGKGRHSAALNFGDCLTYAAAMVAGEPLLCIGDDFPQTDLELVKLGED

Download         Length: 402 bp

>T89156 NZ_CP024894:c4910543-4910142 [Amycolatopsis sp. AA4]
GTGATCATCGACAGTTCCGCGATCGTGGCGGTGCTCATGGAAGAGCCGCTGGCAGTGCCGATCGCCCGGGCGATCGGCGG
CGCGGAGGAATGCCGGATCGGCGCGCCGACCCTGGTGGAGACCTCGATCGTGCTGGCGAACAAGGAAGGCGAGCGAGGCG
CCGCGCTGCTGGCTTCGTTCCTGCAACGGCGGCGGTTCGACGTCCTCACCTTCGGCGAAGCGCACTGGCGGACCGCGCAG
ACCGCGTTCCTGCGGTACGGCAAAGGCAGGCATTCCGCCGCGCTGAACTTCGGCGACTGCCTCACCTACGCGGCCGCGAT
GGTCGCCGGAGAACCGCTGCTCTGCATCGGCGACGACTTCCCGCAAACCGACCTCGAGCTGGTCAAGCTGGGGGAGGACT
GA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10122.45 Da        Isoelectric Point: 5.9067

>AT89156 WP_009079713.1 NZ_CP024894:c4910812-4910540 [Amycolatopsis sp. AA4]
MAMNIKDPETERLAAEVAELTGTTKTGAVRDSLRIMRDRLVAQRRAEHNADEFVRFLREEVWPQVSPENRGKAISKAERE
EILGYGPGGV

Download         Length: 273 bp

>AT89156 NZ_CP024894:c4910812-4910540 [Amycolatopsis sp. AA4]
ATGGCGATGAACATCAAGGATCCGGAAACGGAGCGCCTGGCCGCGGAAGTGGCCGAGCTGACCGGCACTACCAAAACCGG
TGCGGTCCGCGATTCGTTGCGGATCATGCGGGACCGGCTGGTCGCGCAACGGCGTGCGGAGCACAACGCGGACGAGTTCG
TGCGGTTCCTTCGGGAAGAGGTCTGGCCGCAGGTCTCCCCGGAGAACCGGGGCAAGGCGATCAGCAAAGCCGAGCGCGAG
GAAATTCTCGGATACGGGCCGGGTGGCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References