Detailed information of TA system TA089153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4165827..4166647
• Replicon: chromosome
• Accession: NZ_CP024889
• Organism: Escherichia coli strain AR_0019

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AM346_RS21835
• Protein ID: WP_001054379.1
• Coordinates: 4166390..4166647 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AM346_RS21830
• Protein ID: WP_000123957.1
• Coordinates: 4165827..4166378 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM346_RS21805	4161521..4162834	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
AM346_RS21810	4162846..4163124	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AM346_RS21815	4163121..4164242	-	1122	WP_000010833.1	M42 family metallopeptidase	-
AM346_RS24565	4164487..4164603	-	117	Protein_3868	VOC family protein	-
AM346_RS21820	4164641..4164901	-	261	WP_000077646.1	hypothetical protein	-
AM346_RS21825	4165029..4165775	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AM346_RS21830	4165827..4166378	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AM346_RS21835	4166390..4166647	-	258	WP_001054379.1	YjhX family toxin	Toxin
AM346_RS21845	4167024..4167323	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
AM346_RS21850	4167401..4168627	+	1227	Protein_3874	helicase YjhR	-
AM346_RS21855	4169210..4170190	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
AM346_RS21860	4170254..4171360	-	1107	WP_001295733.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T89153 WP_001054379.1 NZ_CP024889:c4166647-4166390 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T89153 NZ_CP024889:c4166647-4166390 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT89153 WP_000123957.1 NZ_CP024889:c4166378-4165827 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT89153 NZ_CP024889:c4166378-4165827 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030