89150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3722366..3723033 Replicon chromosome
Accession NZ_CP024889
Organism Escherichia coli strain AR_0019

Toxin (Protein)


Gene name ypjF Uniprot ID E1IS66
Locus tag AM346_RS19520 Protein ID WP_000856973.1
Coordinates 3722713..3723033 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID E1IS67
Locus tag AM346_RS19515 Protein ID WP_000052843.1
Coordinates 3722366..3722692 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM346_RS19485 3717878..3718567 + 690 WP_000115588.1 WYL domain-containing protein -
AM346_RS19490 3718629..3719639 + 1011 WP_001348677.1 hypothetical protein -
AM346_RS19500 3719878..3721055 + 1178 WP_085968792.1 IS3 family transposase -
AM346_RS19505 3721077..3721814 + 738 Protein_3453 DUF932 domain-containing protein -
AM346_RS19510 3721883..3722353 + 471 WP_001275770.1 DNA repair protein RadC -
AM346_RS19515 3722366..3722692 + 327 WP_000052843.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM346_RS19520 3722713..3723033 + 321 WP_000856973.1 TA system toxin CbtA family protein Toxin
AM346_RS19530 3723800..3724984 + 1185 WP_001172876.1 sugar efflux transporter -
AM346_RS19535 3725095..3726018 + 924 WP_000535971.1 carboxylate/amino acid/amine transporter -
AM346_RS19540 3726022..3726840 - 819 WP_000779426.1 lipoprotein NlpA -
AM346_RS19550 3727062..3727355 + 294 WP_000805509.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12080.87 Da        Isoelectric Point: 5.5873

>T89150 WP_000856973.1 NZ_CP024889:3722713-3723033 [Escherichia coli]
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

>T89150 NZ_CP024889:3722713-3723033 [Escherichia coli]
ATGAAAACTCAACCTGCAACAACTCCGCAGGCGGCGAAGCCATGTCTGTCGCCCCTGGCTGTCTGGCAAATGTTACTGAC
AAGCCTGCTAGACCAGCACTATGGTCTCACGCTAAACGACACGCCGTTCAGTGATGAAACTGTTATTCAGAAACACATTG
AGGCAGGTATTACCTTGGCCGATGCCGTAAACTTTCTGGTTGAACGCTATGAACTAGTTCGTATTGACCAAAAAGGCTTC
TCTGTGCAAGATCAAGAACCTTGGTTAACCTCTATGGATGTTCACCGAGCACGATTTAAACTCAACGTGGAACGTTTATA
A

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12305.01 Da        Isoelectric Point: 6.3620

>AT89150 WP_000052843.1 NZ_CP024889:3722366-3722692 [Escherichia coli]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp

>AT89150 NZ_CP024889:3722366-3722692 [Escherichia coli]
ATGTCATTAATACCAGCCCATGAATGGGGACTACAAAGAGAAATTGTTCCACGGTTTGGAGCCAGATTAGTTCAGGAGGG
CAACCGGCTGCATTATCTGGCTGACAGGGCTAATTTGATGGGCAATTTCAGCGATACGGAATGCTTCAAATTGAATGACG
CATTTCCACACTTTATCAGTCAGATGGAATCGATGCTGACCACTGGTGAACTAATCCCCTGTCACCATCACTGTGTCACT
CTCTACCACAACGGTTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTGTACATCGCGGTTTATCCCACTCA
ACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345ENE3

Antitoxin

Source ID Structure
AlphaFold DB A0A345ENE4

References