Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1227004..1227839 | Replicon | chromosome |
| Accession | NZ_CP024889 | ||
| Organism | Escherichia coli strain AR_0019 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | E1IWA7 |
| Locus tag | AM346_RS06700 | Protein ID | WP_000854751.1 |
| Coordinates | 1227004..1227381 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | E3PJ72 |
| Locus tag | AM346_RS06705 | Protein ID | WP_001278232.1 |
| Coordinates | 1227471..1227839 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM346_RS06660 | 1222397..1222870 | + | 474 | WP_100266631.1 | DNA gyrase inhibitor SbmC | - |
| AM346_RS06665 | 1223068..1223748 | + | 681 | WP_073520313.1 | FUSC family protein | - |
| AM346_RS06670 | 1223812..1224792 | + | 981 | WP_000399648.1 | IS110-like element IS621 family transposase | - |
| AM346_RS06675 | 1224887..1225405 | + | 519 | Protein_1133 | hypothetical protein | - |
| AM346_RS06680 | 1225577..1225906 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| AM346_RS06685 | 1226007..1226189 | - | 183 | WP_001016348.1 | hypothetical protein | - |
| AM346_RS06690 | 1226261..1226389 | + | 129 | Protein_1136 | transposase domain-containing protein | - |
| AM346_RS24315 | 1226678..1226791 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| AM346_RS06695 | 1226804..1227007 | - | 204 | WP_000761704.1 | hypothetical protein | - |
| AM346_RS06700 | 1227004..1227381 | - | 378 | WP_000854751.1 | TA system toxin CbtA family protein | Toxin |
| AM346_RS06705 | 1227471..1227839 | - | 369 | WP_001278232.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| AM346_RS06710 | 1228002..1228223 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| AM346_RS06715 | 1228286..1228762 | - | 477 | WP_001186726.1 | RadC family protein | - |
| AM346_RS06720 | 1228778..1229263 | - | 486 | WP_000849582.1 | antirestriction protein | - |
| AM346_RS06725 | 1229318..1230136 | - | 819 | WP_001234630.1 | DUF945 domain-containing protein | - |
| AM346_RS06735 | 1230236..1230469 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| AM346_RS06740 | 1230548..1231003 | - | 456 | WP_000581504.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1223812..1224792 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14050.04 Da Isoelectric Point: 8.2905
>T89136 WP_000854751.1 NZ_CP024889:c1227381-1227004 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T89136 NZ_CP024889:c1227381-1227004 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCCCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCCCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13491.37 Da Isoelectric Point: 6.6290
>AT89136 WP_001278232.1 NZ_CP024889:c1227839-1227471 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT89136 NZ_CP024889:c1227839-1227471 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|