Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4087190..4087929 Replicon chromosome
Accession NZ_CP024885
Organism Klebsiella aerogenes strain AR_0009

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag AM336_RS20475 Protein ID WP_032705770.1
Coordinates 4087190..4087675 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag AM336_RS20480 Protein ID WP_015366659.1
Coordinates 4087663..4087929 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM336_RS20455 4082737..4083807 - 1071 WP_015366664.1 mannonate dehydratase -
AM336_RS20460 4084068..4084226 + 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
AM336_RS20465 4084283..4085383 - 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
AM336_RS20470 4085502..4087118 - 1617 WP_015366662.1 FAD-NAD(P)-binding protein -
AM336_RS20475 4087190..4087675 - 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
AM336_RS20480 4087663..4087929 - 267 WP_015366659.1 DUF1778 domain-containing protein Antitoxin
AM336_RS20485 4088202..4089437 + 1236 WP_015366658.1 MFS transporter -
AM336_RS20490 4089492..4090025 - 534 WP_100280375.1 N-acetyltransferase -
AM336_RS20495 4090426..4090923 - 498 WP_015366656.1 heme-binding protein -
AM336_RS20500 4091019..4091498 - 480 Protein_3802 response regulator transcription factor -
AM336_RS20505 4091752..4092621 - 870 WP_015366654.1 5'/3'-nucleotidase SurE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T89077 WP_032705770.1 NZ_CP024885:c4087675-4087190 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T89077 NZ_CP024885:c4087675-4087190 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCACAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACTCGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTGTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCAACCACCCAGGAACGCACTCTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT89077 WP_015366659.1 NZ_CP024885:c4087929-4087663 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT89077 NZ_CP024885:c4087929-4087663 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCTTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACTCCGCTCTCGATAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References