89076

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2789265..2789884 Replicon chromosome
Accession NZ_CP024885
Organism Klebsiella aerogenes strain AR_0009

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag AM336_RS14020 Protein ID WP_015367918.1
Coordinates 2789265..2789483 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag AM336_RS14025 Protein ID WP_015367917.1
Coordinates 2789510..2789884 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM336_RS13990 2785338..2785598 + 261 WP_015367923.1 type B 50S ribosomal protein L31 -
AM336_RS13995 2785601..2785741 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AM336_RS14000 2785738..2786448 - 711 WP_015367922.1 GNAT family N-acetyltransferase -
AM336_RS14005 2786551..2788005 + 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
AM336_RS14010 2787980..2788444 - 465 WP_015367920.1 YlaC family protein -
AM336_RS14015 2788570..2789133 - 564 WP_015367919.1 maltose O-acetyltransferase -
AM336_RS14020 2789265..2789483 - 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
AM336_RS14025 2789510..2789884 - 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
AM336_RS14030 2790357..2793503 - 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
AM336_RS14035 2793526..2794725 - 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T89076 WP_015367918.1 NZ_CP024885:c2789483-2789265 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T89076 NZ_CP024885:c2789483-2789265 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT89076 WP_015367917.1 NZ_CP024885:c2789884-2789510 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT89076 NZ_CP024885:c2789884-2789510 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References