Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 672422..673079 Replicon chromosome
Accession NZ_CP024885
Organism Klebsiella aerogenes strain AR_0009

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag AM336_RS03515 Protein ID WP_015369792.1
Coordinates 672422..672832 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag AM336_RS03520 Protein ID WP_015369791.1
Coordinates 672813..673079 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM336_RS03495 668421..670154 - 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -
AM336_RS03500 670160..670873 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM336_RS03505 670896..671792 - 897 WP_015369794.1 site-specific tyrosine recombinase XerD -
AM336_RS03510 671893..672414 + 522 WP_015369793.1 flavodoxin FldB -
AM336_RS03515 672422..672832 - 411 WP_015369792.1 protein YgfX Toxin
AM336_RS03520 672813..673079 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
AM336_RS03525 673303..674286 + 984 WP_015369790.1 tRNA-modifying protein YgfZ -
AM336_RS03530 674385..675044 - 660 WP_008806429.1 hemolysin III family protein -
AM336_RS03535 675209..675520 - 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
AM336_RS03540 675571..676299 + 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
AM336_RS03545 676419..677852 + 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T89073 WP_015369792.1 NZ_CP024885:c672832-672422 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T89073 NZ_CP024885:c672832-672422 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTAATCGACTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAGCCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT89073 WP_015369791.1 NZ_CP024885:c673079-672813 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT89073 NZ_CP024885:c673079-672813 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGATAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References