Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 334772..335552 Replicon chromosome
Accession NZ_CP024885
Organism Klebsiella aerogenes strain AR_0009

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag AM336_RS01795 Protein ID WP_015370123.1
Coordinates 335223..335552 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AM336_RS01790 Protein ID WP_127175768.1
Coordinates 334772..335170 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM336_RS01740 330231..330638 + 408 WP_032710459.1 hypothetical protein -
AM336_RS01745 330711..330938 + 228 WP_015370132.1 hypothetical protein -
AM336_RS01750 330938..331183 + 246 WP_032710460.1 hypothetical protein -
AM336_RS01755 331241..332077 + 837 WP_015370130.1 hypothetical protein -
AM336_RS01760 332171..332404 + 234 WP_015370129.1 DUF905 domain-containing protein -
AM336_RS01765 332502..333320 + 819 WP_015370128.1 DUF945 domain-containing protein -
AM336_RS01770 333320..333574 + 255 WP_071647618.1 hypothetical protein -
AM336_RS01775 333591..334070 + 480 WP_032710462.1 antirestriction protein -
AM336_RS01780 334082..334561 + 480 WP_015370126.1 DNA repair protein RadC -
AM336_RS01785 334582..334803 + 222 WP_015370125.1 DUF987 domain-containing protein -
AM336_RS01790 334772..335170 + 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM336_RS01795 335223..335552 + 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
AM336_RS01800 335958..336059 + 102 Protein_327 preprotein translocase -
AM336_RS01805 336218..337018 - 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
AM336_RS01810 337194..337730 - 537 WP_015370121.1 dihydrofolate reductase family protein -
AM336_RS01815 337930..338292 - 363 WP_015370120.1 cupin domain-containing protein -
AM336_RS01820 338368..339186 - 819 WP_198507993.1 AraC family transcriptional regulator -
AM336_RS01825 339514..339741 - 228 WP_071647620.1 DUF1272 domain-containing protein -
AM336_RS26620 340032..340184 + 153 WP_157844032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310072..339186 29114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T89072 WP_015370123.1 NZ_CP024885:335223-335552 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T89072 NZ_CP024885:335223-335552 [Klebsiella aerogenes]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT89072 WP_127175768.1 NZ_CP024885:334772-335170 [Klebsiella aerogenes]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT89072 NZ_CP024885:334772-335170 [Klebsiella aerogenes]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATTGCCGAACCCTGGTGGGGACTCAAAACCACCGTCACGCCGTACTTTGGCGCACGACTGGTGCAGGAAGGCA
ACCGGCTGCATTACCTGGCTGATCGTGCCAGTATCACCGGGACATTCAGCGACGCGGATTTACGCCATCTCGACCAGGCG
TTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACCTCCCGCCATCAGCACCGCATCACGCT
ATATCACAATGGACTGACTTGCGAAGCCGATACACTCGGCTCTTGTGGTTACGTCTACATCGCTATTTATCCCGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References