Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1986695..1987352 Replicon chromosome
Accession NZ_CP024883
Organism Klebsiella aerogenes strain AR_0007

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag AM334_RS09750 Protein ID WP_015369792.1
Coordinates 1986942..1987352 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag AM334_RS09745 Protein ID WP_015369791.1
Coordinates 1986695..1986961 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM334_RS09720 1981922..1983355 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
AM334_RS09725 1983469..1984203 - 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
AM334_RS09730 1984254..1984565 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
AM334_RS09735 1984730..1985389 + 660 WP_008806429.1 hemolysin III family protein -
AM334_RS09740 1985488..1986471 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
AM334_RS09745 1986695..1986961 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
AM334_RS09750 1986942..1987352 + 411 WP_015369792.1 protein YgfX Toxin
AM334_RS09755 1987360..1987881 - 522 WP_015369793.1 flavodoxin FldB -
AM334_RS09760 1987982..1988878 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
AM334_RS09765 1988901..1989614 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM334_RS09770 1989620..1991353 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T89060 WP_015369792.1 NZ_CP024883:1986942-1987352 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T89060 NZ_CP024883:1986942-1987352 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT89060 WP_015369791.1 NZ_CP024883:1986695-1986961 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT89060 NZ_CP024883:1986695-1986961 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References