Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 542156..542836 Replicon chromosome
Accession NZ_CP024883
Organism Klebsiella aerogenes strain AR_0007

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AM334_RS02560 Protein ID WP_075648423.1
Coordinates 542156..542476 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AM334_RS02565 Protein ID WP_100279254.1
Coordinates 542513..542836 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM334_RS02540 539509..540228 + 720 WP_100279252.1 DNA/RNA non-specific endonuclease -
AM334_RS02545 540343..540687 + 345 WP_045360201.1 DUF1294 domain-containing protein -
AM334_RS02550 541210..542043 - 834 WP_043018277.1 DUF4942 domain-containing protein -
AM334_RS02560 542156..542476 - 321 WP_075648423.1 TA system toxin CbtA family protein Toxin
AM334_RS02565 542513..542836 - 324 WP_100279254.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM334_RS02570 542849..543319 - 471 WP_004186785.1 DNA repair protein RadC -
AM334_RS02575 543390..544211 - 822 WP_100279255.1 DUF945 domain-containing protein -
AM334_RS02580 544321..544731 - 411 WP_100280057.1 hypothetical protein -
AM334_RS02585 544900..545547 - 648 WP_100279256.1 hypothetical protein -
AM334_RS02590 545553..546254 - 702 WP_100279257.1 WYL domain-containing protein -
AM334_RS02595 546467..547342 - 876 WP_100279258.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12037.69 Da        Isoelectric Point: 6.0641

>T89058 WP_075648423.1 NZ_CP024883:c542476-542156 [Klebsiella aerogenes]
MHISSVPATVPVSSRLSPVQVWQQLLTYLLDRHYGLTLNDTPFHNDAAIEEHIEAGITLADAVNFLVERYELVRTDRKGF
SWQEQTPFLTVTDILRAKRATGLMNT

Download         Length: 321 bp

>T89058 NZ_CP024883:c542476-542156 [Klebsiella aerogenes]
ATGCACATTTCATCTGTACCGGCCACGGTGCCGGTCTCGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGATCGCCATTACGGACTGACGCTTAACGACACGCCATTCCACAACGACGCGGCCATTGAGGAACATATTG
AAGCGGGAATAACACTTGCTGATGCGGTGAATTTCCTGGTGGAACGCTATGAACTGGTTCGCACTGACCGTAAGGGTTTC
AGTTGGCAGGAGCAGACGCCATTCCTGACCGTCACCGATATTCTCAGAGCAAAGCGTGCTACCGGGCTGATGAATACGTA
A

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12019.73 Da        Isoelectric Point: 6.8576

>AT89058 WP_100279254.1 NZ_CP024883:c542836-542513 [Klebsiella aerogenes]
MSITPPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGSFSPMHLQKIDLAFPLFVEQLEDMQRAGKLNPHQQHQVT
IQLASLTCIADTRGSCGYVYISIYPAQ

Download         Length: 324 bp

>AT89058 NZ_CP024883:c542836-542513 [Klebsiella aerogenes]
ATGTCAATCACACCACCTCATGAATGGGGTCTACAAAGCGATATCACCCCTCGATTTGGCGCTAGATTAGTTCAGGAAGG
CAACCGGCTGTATTACCTGGCTGACAGGGCTGGATTGACGGGGAGTTTTAGCCCAATGCACCTGCAGAAAATAGATCTGG
CTTTCCCGCTGTTTGTCGAACAACTGGAGGATATGCAGCGTGCTGGCAAACTAAATCCACATCAGCAACATCAGGTGACA
ATTCAGCTTGCGAGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCAGCCCA
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References