Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 102418..102944 | Replicon | plasmid unitig_1_pilon |
| Accession | NZ_CP024882 | ||
| Organism | Citrobacter freundii strain AR_0022 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AM349_RS24785 | Protein ID | WP_000323025.1 |
| Coordinates | 102657..102944 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AM349_RS24780 | Protein ID | WP_000534858.1 |
| Coordinates | 102418..102657 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM349_RS24745 | 97574..97924 | + | 351 | Protein_99 | DUF1281 domain-containing protein | - |
| AM349_RS24750 | 97923..98183 | + | 261 | WP_100280323.1 | hypothetical protein | - |
| - | 98232..98356 | + | 125 | NuclAT_0 | - | - |
| - | 98232..98356 | + | 125 | NuclAT_0 | - | - |
| - | 98232..98356 | + | 125 | NuclAT_0 | - | - |
| - | 98232..98356 | + | 125 | NuclAT_0 | - | - |
| AM349_RS24760 | 98477..99817 | + | 1341 | WP_058671058.1 | ISNCY family transposase | - |
| AM349_RS24765 | 100460..101032 | + | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| AM349_RS24770 | 101232..102155 | + | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| AM349_RS24780 | 102418..102657 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AM349_RS24785 | 102657..102944 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AM349_RS24790 | 103016..103174 | + | 159 | WP_079897042.1 | type I toxin-antitoxin system Hok family toxin | - |
| AM349_RS25010 | 103217..103396 | + | 180 | WP_131403754.1 | hypothetical protein | - |
| AM349_RS24805 | 103955..104248 | + | 294 | WP_061548396.1 | hypothetical protein | - |
| AM349_RS24810 | 104260..105081 | + | 822 | WP_061548395.1 | DUF945 domain-containing protein | - |
| AM349_RS24815 | 105111..105644 | - | 534 | WP_061548394.1 | lytic transglycosylase domain-containing protein | - |
| AM349_RS24820 | 106299..106691 | + | 393 | WP_100280319.1 | relaxosome protein TraM | - |
| AM349_RS24825 | 106723..107364 | - | 642 | WP_061548344.1 | Arc family DNA-binding protein | - |
| AM349_RS24830 | 107563..107916 | + | 354 | WP_061548345.1 | conjugal transfer protein TraA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..115736 | 115736 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T89057 WP_000323025.1 NZ_CP024882:102657-102944 [Citrobacter freundii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T89057 NZ_CP024882:102657-102944 [Citrobacter freundii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT89057 WP_000534858.1 NZ_CP024882:102418-102657 [Citrobacter freundii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT89057 NZ_CP024882:102418-102657 [Citrobacter freundii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|