Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4984353..4984984 Replicon chromosome
Accession NZ_CP024880
Organism Klebsiella aerogenes strain AR_0018

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag AM345_RS24765 Protein ID WP_015703741.1
Coordinates 4984709..4984984 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag AM345_RS24760 Protein ID WP_015703740.1
Coordinates 4984353..4984712 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM345_RS24735 4980610..4981554 + 945 WP_045365244.1 nickel ABC transporter permease subunit NikB -
AM345_RS24740 4981551..4982384 + 834 WP_015369278.1 nickel ABC transporter permease subunit NikC -
AM345_RS24745 4982384..4983148 + 765 WP_047048341.1 nickel import ATP-binding protein NikD -
AM345_RS24750 4983145..4983936 + 792 WP_100279123.1 nickel import ATP-binding protein NikE -
AM345_RS24755 4983924..4984325 + 402 WP_048231413.1 nickel-responsive transcriptional regulator NikR -
AM345_RS24760 4984353..4984712 - 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM345_RS24765 4984709..4984984 - 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
AM345_RS24770 4985381..4986394 + 1014 WP_015369274.1 magnesium transporter -
AM345_RS24775 4986435..4987628 - 1194 WP_020077743.1 NAD(P)/FAD-dependent oxidoreductase -
AM345_RS24780 4987859..4989355 + 1497 WP_015369272.1 inorganic phosphate transporter PitA -
AM345_RS24785 4989421..4989756 - 336 WP_015703743.1 universal stress protein UspB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T89041 WP_015703741.1 NZ_CP024880:c4984984-4984709 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T89041 NZ_CP024880:c4984984-4984709 [Klebsiella aerogenes]
ATGGAGCAGCAGGTTTTATCTTTACGTAAAAAACAGCGCAACACGCTGGAGCAGCTGTTTAAAACCCCCGTGCCGCAGGG
TATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGTGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCACCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT89041 WP_015703740.1 NZ_CP024880:c4984712-4984353 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT89041 NZ_CP024880:c4984712-4984353 [Klebsiella aerogenes]
ATGATCAAACCTAAAACGCCAAATTCAATGGAGATTGCCGGGCAGCCTGCTGTTATTAACTACGTGCCTGAACTCAATGC
ATTCCGCGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGCATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAATATCTTGCTGATTGTCGTGAAGCGGGCATCGAGCCTTATGCTCAGCCGGAAAAGCTGAAAACC
TTCACATTGCGCTATCCTGAATCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCAGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References