Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4935370..4935956 Replicon chromosome
Accession NZ_CP024880
Organism Klebsiella aerogenes strain AR_0018

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag AM345_RS24485 Protein ID WP_002920800.1
Coordinates 4935370..4935738 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag AM345_RS24490 Protein ID WP_004174006.1
Coordinates 4935735..4935956 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM345_RS24465 4930854..4931924 - 1071 WP_049035288.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
AM345_RS24470 4931926..4932771 - 846 WP_015369329.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
AM345_RS24475 4932768..4933655 - 888 WP_045375777.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
AM345_RS24480 4933762..4935078 - 1317 WP_047042950.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
AM345_RS24485 4935370..4935738 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AM345_RS24490 4935735..4935956 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AM345_RS24495 4936120..4936833 - 714 WP_086538103.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
AM345_RS24500 4936851..4937618 - 768 WP_015369325.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
AM345_RS24505 4937615..4938892 - 1278 WP_015369324.1 branched chain amino acid ABC transporter permease LivM -
AM345_RS24510 4938889..4939815 - 927 WP_015369323.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4930117..4940978 10861


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T89040 WP_002920800.1 NZ_CP024880:c4935738-4935370 [Klebsiella aerogenes]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T89040 NZ_CP024880:c4935738-4935370 [Klebsiella aerogenes]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCTGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT89040 WP_004174006.1 NZ_CP024880:c4935956-4935735 [Klebsiella aerogenes]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT89040 NZ_CP024880:c4935956-4935735 [Klebsiella aerogenes]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References