Detailed information of TA system TA089039

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4416057..4416714
• Replicon: chromosome
• Accession: NZ_CP024880
• Organism: Klebsiella aerogenes strain AR_0018

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AM345_RS21805
• Protein ID: WP_020077981.1
• Coordinates: 4416057..4416467 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0H3FJK6
• Locus tag: AM345_RS21810
• Protein ID: WP_015369791.1
• Coordinates: 4416448..4416714 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM345_RS21785	4412056..4413789	-	1734	WP_032715785.1	single-stranded-DNA-specific exonuclease RecJ	-
AM345_RS21790	4413795..4414508	-	714	WP_048231333.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AM345_RS21795	4414531..4415427	-	897	WP_047080361.1	site-specific tyrosine recombinase XerD	-
AM345_RS21800	4415528..4416049	+	522	WP_015369793.1	flavodoxin FldB	-
AM345_RS21805	4416057..4416467	-	411	WP_020077981.1	protein YgfX	Toxin
AM345_RS21810	4416448..4416714	-	267	WP_015369791.1	FAD assembly factor SdhE	Antitoxin
AM345_RS21815	4416938..4417921	+	984	WP_015369790.1	tRNA-modifying protein YgfZ	-
AM345_RS21820	4418020..4418679	-	660	WP_008806429.1	hemolysin III family protein	-
AM345_RS21825	4418844..4419155	-	312	WP_048231334.1	N(4)-acetylcytidine aminohydrolase	-
AM345_RS21830	4419206..4419934	+	729	WP_048231335.1	MurR/RpiR family transcriptional regulator	-
AM345_RS21835	4420054..4421487	+	1434	WP_032712496.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15873.66 Da
• Isoelectric Point: 10.0200

>T89039 WP_020077981.1 NZ_CP024880:c4416467-4416057 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAESGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Nucleotide

• Length: 411 bp

>T89039 NZ_CP024880:c4416467-4416057 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAAGCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10579.09 Da
• Isoelectric Point: 5.6963

>AT89039 WP_015369791.1 NZ_CP024880:c4416714-4416448 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT89039 NZ_CP024880:c4416714-4416448 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3FJK6