Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4956807..4957464 Replicon chromosome
Accession NZ_CP024874
Organism Klebsiella pneumoniae strain NH25

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CU111_RS24770 Protein ID WP_002916310.1
Coordinates 4957054..4957464 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CU111_RS24765 Protein ID WP_002916312.1
Coordinates 4956807..4957073 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU111_RS24740 4951963..4953396 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
CU111_RS24745 4953515..4954243 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CU111_RS24750 4954293..4954604 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CU111_RS24755 4954768..4955427 + 660 WP_002916317.1 hemolysin III family protein -
CU111_RS24760 4955578..4956561 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
CU111_RS24765 4956807..4957073 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CU111_RS24770 4957054..4957464 + 411 WP_002916310.1 protein YgfX Toxin
CU111_RS24775 4957471..4957992 - 522 WP_004144730.1 flavodoxin FldB -
CU111_RS24780 4958093..4958989 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CU111_RS24785 4959012..4959725 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CU111_RS24790 4959731..4961464 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T89023 WP_002916310.1 NZ_CP024874:4957054-4957464 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T89023 NZ_CP024874:4957054-4957464 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT89023 WP_002916312.1 NZ_CP024874:4956807-4957073 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT89023 NZ_CP024874:4956807-4957073 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References