Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3570068..3570584 Replicon chromosome
Accession NZ_CP024874
Organism Klebsiella pneumoniae strain NH25

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag CU111_RS17755 Protein ID WP_004178374.1
Coordinates 3570068..3570352 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CU111_RS17760 Protein ID WP_002886901.1
Coordinates 3570342..3570584 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU111_RS17735 3565552..3565860 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
CU111_RS30985 3565945..3566118 + 174 WP_032408826.1 hypothetical protein -
CU111_RS17740 3566121..3566864 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CU111_RS17745 3567221..3569359 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CU111_RS17750 3569600..3570064 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CU111_RS17755 3570068..3570352 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CU111_RS17760 3570342..3570584 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CU111_RS17765 3570662..3572572 - 1911 WP_004178373.1 BglG family transcription antiterminator -
CU111_RS17770 3572595..3573749 - 1155 WP_004178372.1 lactonase family protein -
CU111_RS17775 3573816..3574556 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T89018 WP_004178374.1 NZ_CP024874:c3570352-3570068 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T89018 NZ_CP024874:c3570352-3570068 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT89018 WP_002886901.1 NZ_CP024874:c3570584-3570342 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT89018 NZ_CP024874:c3570584-3570342 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References