Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1607106..1607941 Replicon chromosome
Accession NZ_CP024862
Organism Escherichia coli strain AR_0015

Toxin (Protein)


Gene name yeeV Uniprot ID B1LDL9
Locus tag AM342_RS08135 Protein ID WP_001094444.1
Coordinates 1607564..1607941 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag AM342_RS08130 Protein ID WP_001285607.1
Coordinates 1607106..1607474 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM342_RS08095 1602998..1603678 + 681 WP_001282919.1 WYL domain-containing protein -
AM342_RS08100 1603826..1604503 + 678 WP_001097301.1 hypothetical protein -
AM342_RS08105 1604533..1604742 + 210 WP_032150870.1 DUF905 family protein -
AM342_RS08110 1604832..1605650 + 819 WP_001175175.1 DUF945 domain-containing protein -
AM342_RS08115 1605742..1606227 + 486 WP_000213722.1 antirestriction protein -
AM342_RS08120 1606242..1606718 + 477 WP_001384029.1 RadC family protein -
AM342_RS08125 1606805..1607026 + 222 WP_000692350.1 DUF987 domain-containing protein -
AM342_RS08130 1607106..1607474 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM342_RS08135 1607564..1607941 + 378 WP_001094444.1 TA system toxin CbtA family protein Toxin
AM342_RS08140 1607938..1608087 + 150 Protein_1510 hypothetical protein -
AM342_RS08145 1608163..1608360 + 198 WP_023563519.1 DUF957 domain-containing protein -
AM342_RS08150 1608445..1609288 + 844 Protein_1512 DUF4942 domain-containing protein -
AM342_RS08155 1609631..1609801 + 171 Protein_1513 IS110 family transposase -
AM342_RS08160 1610612..1611595 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
AM342_RS08165 1611667..1612815 + 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1566239..1609415 43176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14087.02 Da        Isoelectric Point: 7.3523

>T88950 WP_001094444.1 NZ_CP024862:1607564-1607941 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T88950 NZ_CP024862:1607564-1607941 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT88950 WP_001285607.1 NZ_CP024862:1607106-1607474 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT88950 NZ_CP024862:1607106-1607474 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1LDL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References