Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 68646..69172 | Replicon | chromosome |
Accession | NZ_CP024862 | ||
Organism | Escherichia coli strain AR_0015 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | AM342_RS00350 | Protein ID | WP_000323025.1 |
Coordinates | 68646..68933 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | AM342_RS00355 | Protein ID | WP_000534858.1 |
Coordinates | 68933..69172 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM342_RS00305 | 63730..64188 | - | 459 | WP_000526135.1 | IS200/IS605 family transposase | - |
AM342_RS00315 | 64639..64854 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
AM342_RS00320 | 65155..65367 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
AM342_RS28190 | 65422..65511 | + | 90 | WP_120795389.1 | hypothetical protein | - |
AM342_RS00325 | 65789..66541 | - | 753 | WP_001047135.1 | antitermination protein | - |
AM342_RS00330 | 66555..67604 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
AM342_RS00335 | 67606..67884 | - | 279 | WP_012304870.1 | hypothetical protein | - |
AM342_RS00340 | 67951..68202 | - | 252 | WP_000980994.1 | hypothetical protein | - |
AM342_RS00345 | 68419..68574 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
AM342_RS00350 | 68646..68933 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
AM342_RS00355 | 68933..69172 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
AM342_RS00360 | 69197..69502 | + | 306 | WP_001326990.1 | hypothetical protein | - |
AM342_RS00365 | 69705..70037 | + | 333 | WP_001301033.1 | protein FlxA | - |
AM342_RS00375 | 70474..71787 | - | 1314 | WP_000589005.1 | ISNCY family transposase | - |
AM342_RS00380 | 72271..73299 | - | 1029 | WP_001345551.1 | DUF4868 domain-containing protein | - |
AM342_RS00385 | 73296..73910 | - | 615 | WP_001265627.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 35753..86397 | 50644 | |
- | flank | IS/Tn | - | - | 63730..64188 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T88937 WP_000323025.1 NZ_CP024862:c68933-68646 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T88937 NZ_CP024862:c68933-68646 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT88937 WP_000534858.1 NZ_CP024862:c69172-68933 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT88937 NZ_CP024862:c69172-68933 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|