88937

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 68646..69172 Replicon chromosome
Accession NZ_CP024862
Organism Escherichia coli strain AR_0015

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag AM342_RS00350 Protein ID WP_000323025.1
Coordinates 68646..68933 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag AM342_RS00355 Protein ID WP_000534858.1
Coordinates 68933..69172 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM342_RS00305 63730..64188 - 459 WP_000526135.1 IS200/IS605 family transposase -
AM342_RS00315 64639..64854 - 216 WP_000066484.1 cold shock-like protein CspB -
AM342_RS00320 65155..65367 + 213 WP_000087756.1 cold shock-like protein CspF -
AM342_RS28190 65422..65511 + 90 WP_120795389.1 hypothetical protein -
AM342_RS00325 65789..66541 - 753 WP_001047135.1 antitermination protein -
AM342_RS00330 66555..67604 - 1050 WP_001265199.1 DUF968 domain-containing protein -
AM342_RS00335 67606..67884 - 279 WP_012304870.1 hypothetical protein -
AM342_RS00340 67951..68202 - 252 WP_000980994.1 hypothetical protein -
AM342_RS00345 68419..68574 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
AM342_RS00350 68646..68933 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
AM342_RS00355 68933..69172 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AM342_RS00360 69197..69502 + 306 WP_001326990.1 hypothetical protein -
AM342_RS00365 69705..70037 + 333 WP_001301033.1 protein FlxA -
AM342_RS00375 70474..71787 - 1314 WP_000589005.1 ISNCY family transposase -
AM342_RS00380 72271..73299 - 1029 WP_001345551.1 DUF4868 domain-containing protein -
AM342_RS00385 73296..73910 - 615 WP_001265627.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 35753..86397 50644
- flank IS/Tn - - 63730..64188 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T88937 WP_000323025.1 NZ_CP024862:c68933-68646 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T88937 NZ_CP024862:c68933-68646 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT88937 WP_000534858.1 NZ_CP024862:c69172-68933 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT88937 NZ_CP024862:c69172-68933 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References