Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4496384..4497215 Replicon chromosome
Accession NZ_CP024859
Organism Escherichia coli strain AR_0014

Toxin (Protein)


Gene name yeeV Uniprot ID F4THW6
Locus tag AM341_RS22910 Protein ID WP_000854818.1
Coordinates 4496384..4496758 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag AM341_RS22915 Protein ID WP_001313071.1
Coordinates 4496847..4497215 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM341_RS22875 4491788..4493008 + 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
AM341_RS22880 4493065..4493538 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
AM341_RS22885 4493736..4494794 + 1059 WP_001200905.1 FUSC family protein -
AM341_RS22890 4494966..4495295 + 330 WP_000450409.1 DUF496 family protein -
AM341_RS22895 4495396..4495578 - 183 WP_001016348.1 hypothetical protein -
AM341_RS22900 4495632..4495778 + 147 Protein_4169 transposase domain-containing protein -
AM341_RS26415 4496067..4496180 - 114 WP_001161660.1 DUF957 domain-containing protein -
AM341_RS22905 4496193..4496387 - 195 WP_000988600.1 hypothetical protein -
AM341_RS22910 4496384..4496758 - 375 WP_000854818.1 type IV toxin-antitoxin system toxin CbtA Toxin
AM341_RS22915 4496847..4497215 - 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM341_RS22920 4497295..4497516 - 222 WP_000692301.1 DUF987 domain-containing protein -
AM341_RS22925 4497579..4498055 - 477 WP_001186726.1 RadC family protein -
AM341_RS22930 4498071..4498550 - 480 WP_000860076.1 antirestriction protein -
AM341_RS22935 4498632..4499453 - 822 WP_001234530.1 DUF945 domain-containing protein -
AM341_RS22945 4499674..4499943 - 270 WP_000995808.1 hypothetical protein -
AM341_RS22950 4500022..4500719 - 698 Protein_4179 IS1-like element IS1A family transposase -
AM341_RS22965 4501344..4501889 + 546 WP_000973176.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4491788..4493008 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13972.98 Da        Isoelectric Point: 7.1333

>T88916 WP_000854818.1 NZ_CP024859:c4496758-4496384 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T88916 NZ_CP024859:c4496758-4496384 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT88916 WP_001313071.1 NZ_CP024859:c4497215-4496847 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT88916 NZ_CP024859:c4497215-4496847 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W3PHA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References