Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3417970..3418804 Replicon chromosome
Accession NZ_CP024859
Organism Escherichia coli strain AR_0014

Toxin (Protein)


Gene name yeeV Uniprot ID B7MK10
Locus tag AM341_RS17580 Protein ID WP_000854820.1
Coordinates 3417970..3418347 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag AM341_RS17585 Protein ID WP_001285610.1
Coordinates 3418436..3418804 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM341_RS17545 3413247..3413846 + 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -
AM341_RS17550 3413849..3414826 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
AM341_RS17555 3414823..3416001 + 1179 WP_000094991.1 type II secretion system protein GspL -
AM341_RS17560 3416003..3416539 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
AM341_RS17565 3416906..3417466 - 561 Protein_3184 DUF4942 domain-containing protein -
AM341_RS17570 3417551..3417748 - 198 WP_085949158.1 DUF957 domain-containing protein -
AM341_RS17575 3417776..3417973 - 198 Protein_3186 hypothetical protein -
AM341_RS17580 3417970..3418347 - 378 WP_000854820.1 type IV toxin-antitoxin system toxin CbtA Toxin
AM341_RS17585 3418436..3418804 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM341_RS17590 3418884..3419105 - 222 WP_000692347.1 DUF987 domain-containing protein -
AM341_RS17595 3419192..3419668 - 477 WP_001186193.1 RadC family protein -
AM341_RS17600 3419683..3420162 - 480 WP_000706978.1 antirestriction protein -
AM341_RS17605 3420428..3421246 - 819 WP_001175155.1 DUF945 domain-containing protein -
AM341_RS17610 3421336..3421569 - 234 WP_000883181.1 DUF905 family protein -
AM341_RS17615 3421575..3422252 - 678 WP_001097565.1 hypothetical protein -
AM341_RS17620 3422403..3423083 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14043.12 Da        Isoelectric Point: 7.8839

>T88912 WP_000854820.1 NZ_CP024859:c3418347-3417970 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

>T88912 NZ_CP024859:c3418347-3417970 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT88912 WP_001285610.1 NZ_CP024859:c3418804-3418436 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT88912 NZ_CP024859:c3418804-3418436 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E2KXX6


Antitoxin

Source ID Structure

References