Detailed information of TA system TA088879

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2648347..2649181
• Replicon: chromosome
• Accession: NZ_CP024855
• Organism: Escherichia coli strain AR_0011

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B7MK10
• Locus tag: AM338_RS13525
• Protein ID: WP_000854820.1
• Coordinates: 2648804..2649181 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: AM338_RS13520
• Protein ID: WP_001285610.1
• Coordinates: 2648347..2648715 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM338_RS13485	2644068..2644748	+	681	WP_001278649.1	WYL domain-containing protein	-
AM338_RS13490	2644899..2645576	+	678	WP_001097565.1	hypothetical protein	-
AM338_RS13495	2645582..2645815	+	234	WP_000883181.1	DUF905 family protein	-
AM338_RS13500	2645905..2646723	+	819	WP_001175155.1	DUF945 domain-containing protein	-
AM338_RS27305	2646749..2646889	-	141	WP_000997937.1	hypothetical protein	-
AM338_RS13505	2646989..2647468	+	480	WP_000706978.1	antirestriction protein	-
AM338_RS13510	2647483..2647959	+	477	WP_001186193.1	RadC family protein	-
AM338_RS13515	2648046..2648267	+	222	WP_000692347.1	DUF987 domain-containing protein	-
AM338_RS13520	2648347..2648715	+	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AM338_RS13525	2648804..2649181	+	378	WP_000854820.1	type IV toxin-antitoxin system toxin CbtA	Toxin
AM338_RS13530	2649178..2649375	+	198	Protein_2480	hypothetical protein	-
AM338_RS13535	2649403..2649600	+	198	WP_085949158.1	DUF957 domain-containing protein	-
AM338_RS13540	2649685..2650245	+	561	Protein_2482	DUF4942 domain-containing protein	-
AM338_RS13545	2650612..2651148	-	537	WP_000942785.1	GspM family type II secretion system protein YghD	-
AM338_RS13550	2651150..2652328	-	1179	WP_000094991.1	type II secretion system protein GspL	-
AM338_RS13555	2652325..2653302	-	978	WP_000633209.1	type II secretion system minor pseudopilin GspK	-
AM338_RS13560	2653305..2653904	-	600	WP_001255034.1	type II secretion system minor pseudopilin GspJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14043.12 Da
• Isoelectric Point: 7.8839

>T88879 WP_000854820.1 NZ_CP024855:2648804-2649181 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T88879 NZ_CP024855:2648804-2649181 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT88879 WP_001285610.1 NZ_CP024855:2648347-2648715 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT88879 NZ_CP024855:2648347-2648715 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0E2KXX6