Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 98136..98968 Replicon chromosome
Accession NZ_CP024851
Organism Escherichia coli strain AR_0006

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag AM333_RS00580 Protein ID WP_001094454.1
Coordinates 98594..98968 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag AM333_RS00575 Protein ID WP_001320394.1
Coordinates 98136..98504 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM333_RS00530 93483..94346 + 864 Protein_95 hypothetical protein -
AM333_RS00535 94423..94878 + 456 WP_000581493.1 hypothetical protein -
AM333_RS00540 94957..95190 + 234 WP_001119719.1 DUF905 family protein -
AM333_RS00550 95290..96108 + 819 WP_001234642.1 DUF945 domain-containing protein -
AM333_RS00555 96163..96648 + 486 WP_029701480.1 antirestriction protein -
AM333_RS00560 96664..97140 + 477 WP_001347688.1 RadC family protein -
AM333_RS00565 97203..97424 + 222 WP_000692300.1 DUF987 domain-containing protein -
AM333_RS00570 97443..98086 + 644 Protein_102 antitoxin of toxin-antitoxin stability system -
AM333_RS00575 98136..98504 + 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM333_RS00580 98594..98968 + 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
AM333_RS00585 98965..99453 + 489 WP_000777545.1 hypothetical protein -
AM333_RS00590 99465..99662 + 198 WP_000839276.1 DUF957 domain-containing protein -
AM333_RS00595 99759..100328 + 570 WP_001290250.1 DUF4942 domain-containing protein -
AM333_RS00600 100671..100841 + 171 Protein_108 IS110 family transposase -
AM333_RS00605 101652..102635 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
AM333_RS00610 102707..103855 + 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T88818 WP_001094454.1 NZ_CP024851:98594-98968 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T88818 NZ_CP024851:98594-98968 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT88818 WP_001320394.1 NZ_CP024851:98136-98504 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT88818 NZ_CP024851:98136-98504 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References