Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 609919..610570 Replicon chromosome
Accession NZ_CP024848
Organism Oceanobacillus zhaokaii strain 160

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CUC15_RS03160 Protein ID WP_114915332.1
Coordinates 610208..610570 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag CUC15_RS03155 Protein ID WP_114915331.1
Coordinates 609919..610203 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC15_RS03135 604959..606380 + 1422 WP_114915327.1 PH domain-containing protein -
CUC15_RS03140 606723..607487 - 765 WP_114915328.1 rhomboid family intramembrane serine protease -
CUC15_RS03145 607701..608066 + 366 WP_114915329.1 holo-ACP synthase -
CUC15_RS03150 608443..609477 + 1035 WP_114915330.1 outer membrane lipoprotein carrier protein LolA -
CUC15_RS03155 609919..610203 + 285 WP_114915331.1 antitoxin Antitoxin
CUC15_RS03160 610208..610570 + 363 WP_114915332.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CUC15_RS03165 610758..611627 + 870 WP_114915333.1 RsbT co-antagonist protein RsbRA -
CUC15_RS03170 611624..611989 + 366 WP_205317647.1 STAS domain-containing protein -
CUC15_RS03175 611992..612393 + 402 WP_114915335.1 anti-sigma regulatory factor -
CUC15_RS03180 612489..613502 + 1014 WP_114915336.1 PP2C family protein-serine/threonine phosphatase -
CUC15_RS03185 613606..613950 + 345 WP_114915337.1 anti-sigma factor antagonist -
CUC15_RS03190 613937..614413 + 477 WP_114915338.1 anti-sigma B factor RsbW -
CUC15_RS03195 614385..615176 + 792 WP_114915339.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13473.65 Da        Isoelectric Point: 9.4870

>T88816 WP_114915332.1 NZ_CP024848:610208-610570 [Oceanobacillus zhaokaii]
MIVQRGEVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERNSVILLEQI
RTLDKQRLTDKITKLDNEMMKKINQAVEISLGLKDIYNGH

Download         Length: 363 bp

>T88816 NZ_CP024848:610208-610570 [Oceanobacillus zhaokaii]
TTGATTGTTCAAAGAGGCGAGGTATATTTTGCAGACCTTTCTCCTGTTGTTGGATCAGAGCAGGGGGGCGTTCGTCCGGT
GTTGATCCTACAAAATGATATCGGTAATCGTTTTAGTCCAACTGTCATAGTTGCAGCAATTACCGCACAAATCCAAAAGG
CTAAATTACCAACACATGTCGAGATCGATGCGAAACGATATGGGTTTGAACGTAATTCAGTCATCTTGTTAGAACAAATT
CGGACGTTAGATAAGCAAAGATTAACTGATAAGATTACAAAGTTAGATAATGAAATGATGAAGAAAATTAATCAAGCAGT
AGAGATAAGCCTTGGACTCAAGGATATTTATAATGGCCATTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10866.19 Da        Isoelectric Point: 4.4098

>AT88816 WP_114915331.1 NZ_CP024848:609919-610203 [Oceanobacillus zhaokaii]
MSESLQEVVVKLPKNLLNEVDGLMQYENSNLSDFICQATKNYLQHKKDEHIQQFHETMQRGYVEMGRINLTIASEAFQAE
EEADYTLERSVIGV

Download         Length: 285 bp

>AT88816 NZ_CP024848:609919-610203 [Oceanobacillus zhaokaii]
TTGTCAGAGAGCTTGCAGGAAGTGGTAGTAAAATTACCAAAAAACCTACTAAATGAGGTGGATGGATTAATGCAGTATGA
AAATAGTAATTTAAGTGATTTCATATGTCAGGCTACGAAAAACTATCTACAACATAAAAAAGATGAGCATATACAACAAT
TTCATGAAACAATGCAGCGAGGTTACGTAGAAATGGGCCGCATTAATCTGACAATTGCTTCAGAAGCTTTTCAGGCTGAA
GAGGAGGCTGATTACACCTTAGAGCGCTCTGTGATCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References