Detailed information of TA system TA088815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 1383604..1384082
• Replicon: chromosome
• Accession: NZ_CP024847
• Organism: Aquella oligotrophica strain DSM 100970

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CUN60_RS06300
• Protein ID: WP_102951219.1
• Coordinates: 1383604..1383864 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CUN60_RS06305
• Protein ID: WP_102952450.1
• Coordinates: 1383864..1384082 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUN60_RS06290 (CUN60_06290)	1380170..1382524	+	2355	WP_102951217.1	hypothetical protein	-
CUN60_RS06300 (CUN60_06300)	1383604..1383864	-	261	WP_102951219.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CUN60_RS06305 (CUN60_06305)	1383864..1384082	-	219	WP_102952450.1	DUF6290 family protein	Antitoxin
CUN60_RS13300	1384246..1384368	+	123	WP_279639058.1	hypothetical protein	-
CUN60_RS06310 (CUN60_06310)	1384658..1384987	-	330	WP_102951220.1	hypothetical protein	-
CUN60_RS06315 (CUN60_06315)	1385084..1385311	-	228	WP_102951221.1	hypothetical protein	-
CUN60_RS06320 (CUN60_06320)	1385485..1385694	+	210	WP_102951222.1	anti-toxin	-
CUN60_RS06325 (CUN60_06325)	1385681..1385956	+	276	WP_102951223.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CUN60_RS06330 (CUN60_06330)	1386283..1388805	+	2523	WP_102951224.1	choice-of-anchor D domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-85)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10112.91 Da
• Isoelectric Point: 10.1005

>T88815 WP_102951219.1 NZ_CP024847:c1383864-1383604 [Aquella oligotrophica]
MWAVQFSTKAAKLFDKLDKPVQKQIAAEIDKIIALENPRQSGKALTSELSRLWRYRAEDYRLVCEIQDNILIILVLRIAH
RKEIYK

Nucleotide

• Length: 261 bp

>T88815 NZ_CP024847:c1383864-1383604 [Aquella oligotrophica]
ATGTGGGCTGTCCAGTTTTCTACAAAAGCAGCAAAGTTATTTGACAAGCTAGATAAACCAGTACAAAAACAAATAGCAGC
AGAAATTGATAAAATAATAGCTTTGGAAAATCCTAGGCAGTCAGGCAAGGCACTAACCAGCGAACTTTCCCGATTATGGC
GCTACAGAGCAGAAGATTATCGTCTAGTTTGTGAAATACAAGACAACATATTAATCATACTAGTACTGAGGATTGCACAC
CGTAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8558.68 Da
• Isoelectric Point: 4.6536

>AT88815 WP_102952450.1 NZ_CP024847:c1384082-1383864 [Aquella oligotrophica]
MLAIRLDAEIEQRLNNLAEKTHRTKSFYVKQALIEYLDDMEDIYLAEKELEDIRSGNSTTISWEELKKRNNL

Nucleotide

• Length: 219 bp

>AT88815 NZ_CP024847:c1384082-1383864 [Aquella oligotrophica]
ATGTTAGCAATTAGGCTTGATGCTGAAATAGAGCAAAGATTGAATAACCTTGCTGAAAAAACTCACCGGACTAAGTCTTT
TTATGTCAAACAGGCACTAATAGAGTATTTGGATGATATGGAAGATATATATCTGGCGGAGAAAGAATTAGAGGATATCC
GATCTGGGAATAGTACAACTATTTCGTGGGAAGAGCTAAAAAAACGGAATAACTTATAA